一种α2肾上腺素能受体拮抗剂，Org 3770，可增强人体夜间褪黑素的分泌。
An alpha 2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man.
作者信息
Palazidou E, Papadopoulos A, Sitsen A, Stahl S, Checkley S
机构信息
Institute of Psychiatry, London, UK.
出版信息
Psychopharmacology (Berl). 1989;97(1):115-7. doi: 10.1007/BF00443424.
PMID:2565588
Abstract
Nocturnal plasma melatonin concentration was significantly increased in ten normal volunteers following the administration of an alpha 2 adrenoceptor antagonist, Org 3770 (30 mg). This result supports the existence of an alpha 2 adrenergic influence on melatonin secretion in man and provides a possible clinical neuroendocrine marker of the action of an alpha 2 antagonist.
摘要
在10名正常志愿者服用α2肾上腺素能受体拮抗剂Org 3770（30毫克）后，夜间血浆褪黑素浓度显著升高。这一结果支持了α2肾上腺素能对人体褪黑素分泌有影响的观点，并为α2拮抗剂的作用提供了一种可能的临床神经内分泌标志物。
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