尼卡地平对醛固酮释放及升压机制的影响。
Effects of nicardipine on aldosterone release and pressor mechanisms.
作者信息
Elliott H L, Pasanisi F, Reid J L
出版信息
Br J Clin Pharmacol. 1985;20 Suppl 1(Suppl 1):99S-102S. doi: 10.1111/j.1365-2125.1985.tb05150.x.
Abstract
This study evaluated the effects of nicardipine, following intravenous infusion and oral administration, on the pressor and aldosterone responses to infused angiotensin II. Six healthy, normotensive male subjects were studied. Following administration of nicardipine, no significant change in blood pressure was seen. Nicardipine attenuated the pressor response produced by intravenous administration of angiotensin. Nicardipine did not inhibit the aldosterone response to angiotensin.
摘要
本研究评估了静脉输注和口服尼卡地平后，其对输注血管紧张素II所致升压反应和醛固酮反应的影响。研究了6名健康的血压正常男性受试者。给予尼卡地平后，血压未见明显变化。尼卡地平减弱了静脉注射血管紧张素所产生的升压反应。尼卡地平未抑制对血管紧张素的醛固酮反应。
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