• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

低肾素性高血压患者的分子与临床研究

Molecular and clinical investigations in patients with low-renin hypertension.

作者信息

Mackenzie Isla S, Brown Morris J

机构信息

Hypertension Research Centre, Ninewells Hospital, University of Dundee, Level 7, Dundee, DD1 9SY, UK.

出版信息

Clin Exp Nephrol. 2009 Feb;13(1):1-8. doi: 10.1007/s10157-008-0071-4. Epub 2008 Aug 15.

DOI:10.1007/s10157-008-0071-4
PMID:18704622
Abstract

Interactions between the renin-angiotensin-aldosterone system and other mechanisms determining sodium balance are important in the pathophysiology of hypertension. Low-renin hypertension is a common type of resistant hypertension and is often associated with increased sodium retention. The importance of investigation, factors determining renin and aldosterone levels, and drug therapies in low-renin hypertension are reviewed.

摘要

肾素-血管紧张素-醛固酮系统与其他决定钠平衡的机制之间的相互作用在高血压的病理生理学中很重要。低肾素性高血压是一种常见的难治性高血压类型，常伴有钠潴留增加。本文综述了低肾素性高血压的研究意义、决定肾素和醛固酮水平的因素以及药物治疗。

相似文献

1
Molecular and clinical investigations in patients with low-renin hypertension.低肾素性高血压患者的分子与临床研究
Clin Exp Nephrol. 2009 Feb;13(1):1-8. doi: 10.1007/s10157-008-0071-4. Epub 2008 Aug 15.
2
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activated intrarenal renin-angiotensin system is correlated with high blood pressure in humans.关于“针锋相对”观点的评论：系统性高血压的主要促成因素：交感神经系统的慢性激活与肾内肾素-血管紧张素系统的激活。激活的肾内肾素-血管紧张素系统与人类高血压相关。
J Appl Physiol (1985). 2010 Dec;109(6):2003. doi: 10.1152/japplphysiol.01160.2010.
3
Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension.反驳观点：肾内肾素-血管紧张素系统的激活是系统性高血压的主要促成因素。
J Appl Physiol (1985). 2010 Dec;109(6):1998-2000; discussion 2015. doi: 10.1152/japplphysiol.00182.2010a.
4
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Sympathetic nervous system, plasma volume, and hypertension.关于“针锋相对：系统性高血压的主要促成因素：交感神经系统的慢性激活与肾内肾素 - 血管紧张素系统的激活”的评论。交感神经系统、血容量与高血压。
J Appl Physiol (1985). 2010 Dec;109(6):2003. doi: 10.1152/japplphysiol.01160.2010.
5
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system.关于“针锋相对：系统性高血压的主要促成因素：交感神经系统的慢性激活与肾内肾素 - 血管紧张素系统的激活”的评论
J Appl Physiol (1985). 2010 Dec;109(6):2006-7. doi: 10.1152/japplphysiol.01160.2010.
6
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activation of the sympathetic nervous system is the dominant contributor to systemic hypertension.关于“针锋相对”的评论：系统性高血压的主要促成因素：交感神经系统的慢性激活与肾内肾素 - 血管紧张素系统的激活。交感神经系统的激活是系统性高血压的主要促成因素。
J Appl Physiol (1985). 2010 Dec;109(6):2006.
7
A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model.基于模型的方法研究高血压的病理生理机制及对降压治疗的反应：扩展盖顿模型。
Am J Physiol Regul Integr Comp Physiol. 2014 May;306(9):R647-62. doi: 10.1152/ajpregu.00039.2013. Epub 2014 Feb 5.
8
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system.关于“正方观点：反方观点：系统性高血压的主要促成因素：交感神经系统的慢性激活与肾内肾素 - 血管紧张素系统的激活”的评论
J Appl Physiol (1985). 2010 Dec;109(6):2007.
9
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Dominant contributors for systemic hypertension--who leads, who follows?
J Appl Physiol (1985). 2010 Dec;109(6):2007-8. doi: 10.1152/japplphysiol.01160.2010.
10
Rebuttal from Navar.
J Appl Physiol (1985). 2010 Dec;109(6):2001-2. doi: 10.1152/japplphysiol.00182.2010c.

引用本文的文献

1
ACE Inhibition to Distinguish Low-Renin Hypertension From Primary Aldosteronism.通过血管紧张素转换酶抑制来鉴别低肾素性高血压与原发性醛固酮增多症。
Hypertension. 2025 Jun;82(6):1046-1055. doi: 10.1161/HYPERTENSIONAHA.125.24711. Epub 2025 Mar 31.
2
Salt Sensitivity of Blood Pressure in Black People: The Need to Sort Out Ancestry Versus Epigenetic Versus Social Determinants of Its Causation.黑人血压的盐敏感性：理清其病因中的祖先因素、表观遗传因素与社会决定因素的必要性。
Hypertension. 2024 Mar;81(3):456-467. doi: 10.1161/HYPERTENSIONAHA.123.17951. Epub 2023 Sep 28.
3
Primary aldosteronism: molecular medicine meets public health.

本文引用的文献

1
Expression of the epithelial Na(+) channel and other components of an aldosterone response pathway in human adrenocortical cells.上皮钠通道及醛固酮反应途径其他组分在人肾上腺皮质细胞中的表达
Eur J Pharmacol. 2009 Jun 24;613(1-3):176-81. doi: 10.1016/j.ejphar.2009.04.005. Epub 2009 Apr 14.
2
Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R.二氢吡啶类钙通道阻滞剂贝尼地平对T型电压依赖性Ca2+通道的阻滞作用可抑制人肾上腺皮质细胞系NCI-H295R中醛固酮的产生。
Eur J Pharmacol. 2008 Apr 28;584(2-3):424-34. doi: 10.1016/j.ejphar.2008.02.001. Epub 2008 Feb 12.
3
原发性醛固酮增多症：分子医学与公共卫生的交汇。
Nat Rev Nephrol. 2023 Dec;19(12):788-806. doi: 10.1038/s41581-023-00753-6. Epub 2023 Aug 23.
4
Effect of Chronically Suppressed Plasma Angiotensin II on Regulation of the CYP4A/20-HETE Pathway in the Dahl Salt-Sensitive Rat.长期抑制血浆血管紧张素II对 Dahl 盐敏感大鼠 CYP4A/20-羟基二十碳四烯酸途径调节的影响
Antioxidants (Basel). 2023 Mar 23;12(4):783. doi: 10.3390/antiox12040783.
5
The importance of the epithelial sodium channel in determining salt sensitivity in people of African origin.上皮钠通道在决定非洲裔人群盐敏感性方面的重要性。
Pediatr Nephrol. 2021 Feb;36(2):237-243. doi: 10.1007/s00467-019-04427-z. Epub 2020 Jan 2.
6
Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial.氨氯吡咪与氨氯吡咪加氢氯噻嗪对比氢氯噻嗪对葡萄糖耐量和血压的影响（PATHWAY-3）：一项平行分组、双盲、随机 4 期临床试验。
Lancet Diabetes Endocrinol. 2016 Feb;4(2):136-47. doi: 10.1016/S2213-8587(15)00377-0. Epub 2015 Oct 18.
7
The relevance of the Renin-Angiotensin system in the development of drugs to combat preeclampsia.肾素-血管紧张素系统在开发治疗先兆子痫药物中的相关性。
Int J Endocrinol. 2015;2015:572713. doi: 10.1155/2015/572713. Epub 2015 Apr 27.
8
Primary aldosteronism: A contrarian view.原发性醛固酮增多症：一种相反的观点。
Rev Endocr Metab Disord. 2011 Mar;12(1):49-52. doi: 10.1007/s11154-011-9160-x.
A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity.
一些已上市的二氢吡啶类钙通道阻滞剂具有盐皮质激素受体拮抗剂活性。
Hypertension. 2008 Mar;51(3):742-8. doi: 10.1161/HYPERTENSIONAHA.107.103580. Epub 2008 Feb 4.
4
The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio.螺内酯、氨氯吡咪、氯沙坦与噻嗪类药物（SALT）对低肾素性高血压和醛固酮-肾素比值升高患者的双盲交叉试验。
Circulation. 2007 Jul 17;116(3):268-75. doi: 10.1161/CIRCULATIONAHA.107.690396. Epub 2007 Jul 2.
5
Renin: friend or foe?肾素：是友还是敌？
Heart. 2007 Sep;93(9):1026-33. doi: 10.1136/hrt.2006.107706. Epub 2007 May 8.
6
Prevalence of primary hyperaldosteronism assessed by aldosterone/renin ratio and spironolactone testing.通过醛固酮/肾素比值及螺内酯试验评估原发性醛固酮增多症的患病率。
Clin Med (Lond). 2005 Jan-Feb;5(1):55-60. doi: 10.7861/clinmedicine.5-1-55.
7
Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV.高血压管理指南：英国高血压学会第四届工作组报告，2004年 - BHS IV
J Hum Hypertens. 2004 Mar;18(3):139-85. doi: 10.1038/sj.jhh.1001683.
8
Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronism.药物对原发性醛固酮增多症中醛固酮/血浆肾素活性比值的影响。
Hypertension. 2002 Dec;40(6):897-902. doi: 10.1161/01.hyp.0000038478.59760.41.
9
Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs.五类抗高血压药物的双盲、安慰剂对照交叉比较
J Hypertens. 2002 Apr;20(4):771-7. doi: 10.1097/00004872-200204000-00037.
10
Human hypertension caused by mutations in WNK kinases.由WNK激酶突变引起的人类高血压。
Science. 2001 Aug 10;293(5532):1107-12. doi: 10.1126/science.1062844.