Soh Benjy Yi-Min, Kumar Rajneesh, Ekstrom Victoria Sze-Min, Lin Clement Yi-Hao, Thangaraju Sobhana, Tan Hwee Huang, Chan Kwai Peng, Choong Lina Hui Lin, Teo Diana, Chow Wan Cheng
Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
Duke-NUS Medical School, Singapore.
Singapore Med J. 2019 Jan;60(1):34-39. doi: 10.11622/smedj.2018078. Epub 2018 Jun 21.
To study the prevalence of hepatitis C virus (HCV) infection in blood donor (BD), haemodialysis (HD) and intravenous drug user (IVDU) populations in Singapore and assess the IL28B polymorphism if HCV positive.
The BD population were healthy volunteers, the HD population were patients who were on haemodialysis for at least six months of follow-up between January 2009 and December 2014. IVDU population was from inmates at halfway houses who consented.
Between 2011 and 2014, of 161,658 individuals who underwent screening prior to blood donation, 95 (0.059%) were positive for HCV. Of the 42 sera available, common genotypes (GTs) were GT-3 (47.6%) and GT-1 (31.0%). Of 1,575 HD patients, 2.2% were anti-HCV positive. The HCV GT distribution was HCV GT-1 (32.4%), HCV GT-3 (20.5%) and GT-6 (8.8%). 83 halfway house inmates were screened. Of the 47 IVDUs, 36.2% were anti-HCV positive with predominant GT-3 (%). IL28B polymorphism was noted to be CC predominantly 85.3%.
Prevalence of HCV infection has decreased in both the BD and HD populations. However, it remains high in the IVDU population. GT-1 remains the most common in the HD population; however, GT-3 infection is now more common among the BD population in Singapore. IL28B - CC is the predominant variant among the HCV-infected individuals in Singapore.
研究新加坡献血者（BD）、血液透析（HD）患者及静脉吸毒者（IVDU）人群中丙型肝炎病毒（HCV）感染的流行情况，并在HCV阳性者中评估IL28B基因多态性。
献血者人群为健康志愿者，血液透析人群为2009年1月至2014年12月期间接受至少6个月随访的血液透析患者。静脉吸毒者人群来自同意参与的中途宿舍的 inmates。
2011年至2014年期间，在161,658名献血前接受筛查的个体中，95人（0.059%）HCV呈阳性。在42份可用血清中，常见基因型（GTs）为GT-3（47.6%）和GT-1（31.0%）。在1575名血液透析患者中，2.2%抗-HCV呈阳性。HCV GT分布为HCV GT-1（32.4%）、HCV GT-3（20.5%）和GT-6（8.8%）。对83名中途宿舍 inmates 进行了筛查。在47名静脉吸毒者中，36.2%抗-HCV呈阳性，主要基因型为GT-3（%）。IL28B基因多态性主要为CC型，占85.3%。
献血者和血液透析患者人群中HCV感染率均有所下降。然而，静脉吸毒者人群中的感染率仍然很高。GT-1在血液透析人群中仍然最常见；然而，GT-3感染目前在新加坡献血者人群中更为常见。IL28B - CC是新加坡HCV感染者中的主要变异型。
