Yan Kenneth-K, Guirgis Marianne, Dinh Thuy, George Jacob, Dev Anouk, Lee Alice, Zekry Amany
Department of Medicine, St. George Hospital, Kogarah, Sydney 2217, NSW, Australia.
World J Gastroenterol. 2008 Jun 7;14(21):3416-20. doi: 10.3748/wjg.14.3416.
To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C (CHC) treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians.
Asian patients infected with genotype 1 CHC treated at 4 Australian centres between 2001 to 2005 were identified through hospital databases. Baseline demographic characteristics, biochemical, virological and histological data and details of treatment were collected. Sustained virological responses (SVR) in this cohort were then compared to that in Caucasian subjects, matched by genotype, age, gender and the stage of hepatic fibrosis.
A total of 108 Asians with genotype 1 CHC were identified. The end of treatment response (ETR) for the cohort was 79% while the SVR was 67%. Due to the relatively advanced age of the Asian cohort, only sixty-four subjects could be matched with Caucasians. The ETR among matched Asians and Caucasians was 81% and 56% respectively (P = 0.003), while the SVR rates were 73% and 36% (P < 0.001) respectively. This difference remained significant after adjusting for other predictive variables.
Genotype 1 CHC in Asian subjects is associated with higher rates of virological response compared to that in Caucasians.
对接受干扰素和利巴韦林联合治疗的亚洲基因1型慢性丙型肝炎（CHC）感染者的病毒学应答率进行多中心回顾性研究，并将他们的应答情况与高加索人进行比较。
通过医院数据库识别出2001年至2005年期间在4个澳大利亚中心接受治疗的亚洲基因1型CHC感染者。收集基线人口统计学特征、生化、病毒学和组织学数据以及治疗细节。然后将该队列中的持续病毒学应答（SVR）与按基因型、年龄、性别和肝纤维化阶段匹配的高加索受试者进行比较。
共识别出108例亚洲基因1型CHC感染者。该队列的治疗结束时应答（ETR）为79%，而SVR为67%。由于亚洲队列年龄相对较大，只有64名受试者能与高加索人匹配。匹配的亚洲人和高加索人的ETR分别为81%和56%（P = 0.003），而SVR率分别为73%和36%（P < 0.001）。在调整其他预测变量后，这种差异仍然显著。
与高加索人相比，亚洲受试者的基因1型CHC病毒学应答率更高。
