Ignatov Iu D, Zaĭtsev A A
Biull Eksp Biol Med. 1985 Aug;100(8):201-4.
It has been demonstrated on unrestrained rats that the analgesic effect of clofelin is primarily determined by the influences on the processes of adrenergic but not opioidergic mediation. The functional heterogeneity of receptor substrates involved in the realization of the hemodynamic (alpha 2-) and emotional-behavioral (alpha 1-) components of the analgesic effect of clofelin is suggested.
在未束缚的大鼠身上已证实，氯非林的镇痛作用主要取决于对肾上腺素能而非阿片样物质介导过程的影响。这表明参与氯非林镇痛作用的血流动力学（α2 -）和情绪行为（α1 -）成分实现的受体底物存在功能异质性。
