College of Computer Science and Information Technology, Guangxi Normal University, Guilin, Guangxi, 541004, People's Republic of China.
Guangxi Key Lab of Multi-Source Information Mining and Security, Guilin, Guangxi, 541004, People's Republic of China.
Brain Imaging Behav. 2019 Aug;13(4):953-962. doi: 10.1007/s11682-018-9911-3.
Studying the neural correlates of craving to smoke is of great importance to improve treatment outcomes in smoking addiction. According to previous studies, the critical roles of striatum and frontal brain regions had been revealed in addiction. However, few studies focused on the hub of brain regions in the 12 h abstinence induced craving in young smokers. Thirty-one young male smokers were enrolled in the present study. A within-subject experiment design was carried out to compare functional connectivity density between 12-h smoking abstinence and smoking satiety conditions during resting state in young adult smokers by using functional connectivity density mapping (FCDM). Then, the functional connectivity density changes during smoking abstinence versus satiety were further used to examine correlations with abstinence-induced changes in subjective craving. We found young adult smokers in abstinence state (vs satiety) had higher local functional connectivity density (lFCD) and global functional connectivity density (gFCD) in brain regions including striatal subregions (i.e., bilateral caudate and putamen), frontal regions (i.e., anterior cingulate cortex (ACC) and orbital frontal cortex (OFC)) and bilateral insula. We also found higher lFCD during smoking abstinence (vs satiety) in bilateral thalamus. Additionally, the lFCD changes of the left ACC, bilateral caudate and right OFC were positively correlated with the changes in craving induced by abstinence (i.e., abstinence minus satiety) in young adult smokers. The present findings improve the understanding of the effects of acute smoking abstinence on the hubs of brain gray matter in the abstinence-induces craving and may contribute new insights into the neural mechanism of abstinence-induced craving in young smokers in smoking addiction.
研究吸烟渴求的神经相关性对于提高吸烟成瘾的治疗效果非常重要。根据之前的研究，纹状体和额叶脑区在成瘾中起着关键作用。然而，很少有研究关注在 12 小时戒烟诱发的年轻吸烟者渴求中脑区的枢纽。本研究纳入了 31 名年轻男性吸烟者。采用功能连接密度图（FCDM），对年轻成年吸烟者在静息状态下，12 小时戒烟与吸烟满足条件下的功能连接密度进行了个体内实验设计比较。然后，进一步用功能连接密度变化来检验与戒烟诱发的渴求变化的相关性。我们发现，与吸烟满足状态相比，戒烟状态下的年轻成年吸烟者的大脑区域（包括纹状体的两个亚区（即双侧尾状核和壳核）、额叶区域（即前扣带回皮质和眶额皮质）和双侧岛叶）的局部功能连接密度（lFCD）和全局功能连接密度（gFCD）更高。我们还发现，在双侧丘脑，吸烟戒断期间的 lFCD 更高。此外，左前扣带回、双侧尾状核和右侧眶额皮质的 lFCD 变化与年轻成年吸烟者戒断诱发的渴求变化呈正相关（即戒断减去满足）。本研究结果提高了对急性戒烟对戒烟渴求的大脑灰质枢纽的影响的理解，可能为吸烟成瘾中年轻吸烟者的戒断诱发渴求的神经机制提供新的见解。
