Liu Chang, Dong Fang, Li Yangding, Ren Yan, Xie Dongdong, Wang Xianfu, Xue Ting, Zhang Ming, Ren Guoyin, von Deneen Karen M, Yuan Kai, Yu Dahua
Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, China.
Guangxi Key Laboratory of Multi-Source Information Mining and Security, Guangxi Normal University, Guilin, China.
Front Psychol. 2019 Aug 14;10:1814. doi: 10.3389/fpsyg.2019.01814. eCollection 2019.
Decreased inhibition control ability and increased craving may be the most important causes of relapsing in smoking. Although inhibition control defects in young smokers were investigated, the effects of short-term abstinence on inhibition control in young smokers were still unclear. Thirty young smokers participated in the present study. The EEG signals during the Go/NoGo task were recorded in both satiety and 12 h abstinence conditions. The task performances were observed and compared between the two conditions. Event-related potential (ERP) analysis was used to investigate changes in N200 and P300 amplitude and latency induced by 12 h of abstinence. After 12 h of abstinence, the latency of N200 was prolonged in young smokers. No significant changes were found in the number of NoGo errors and the response time of Go in young smokers after 12 h of abstinence. Correlation analysis showed that the N200 latency of abstinence condition was significantly correlated with the number of NoGo errors and the response time of Go in the abstinence condition. The present findings may improve the understanding of the effect of short-term abstinence in young smokers. We suggested that the latency of N200 may be associated with inefficient inhibitory control of the abstinence condition in young smokers. Our results may contribute new insights into the neural mechanism of nicotine abstinence in young smokers.
抑制控制能力下降和渴望增加可能是吸烟复发的最重要原因。尽管对年轻吸烟者的抑制控制缺陷进行了研究，但短期戒烟对年轻吸烟者抑制控制的影响仍不清楚。30名年轻吸烟者参与了本研究。在饱腹和戒烟12小时的条件下，记录了Go/NoGo任务期间的脑电图信号。观察并比较了两种条件下的任务表现。采用事件相关电位（ERP）分析来研究12小时戒烟引起的N200和P300波幅及潜伏期的变化。戒烟12小时后，年轻吸烟者的N200潜伏期延长。戒烟12小时后，年轻吸烟者的NoGo错误数量和Go反应时间没有显著变化。相关分析表明，戒烟条件下的N200潜伏期与戒烟条件下的NoGo错误数量和Go反应时间显著相关。本研究结果可能会增进对年轻吸烟者短期戒烟效果的理解。我们认为，N200潜伏期可能与年轻吸烟者戒烟条件下抑制控制效率低下有关。我们的结果可能为年轻吸烟者尼古丁戒断的神经机制提供新的见解。
