Imamura Akihiro, Kiso Makoto
Department of Applied Bio-Organic Chemistry, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto, Japan.
Methods Mol Biol. 2018;1804:293-310. doi: 10.1007/978-1-4939-8552-4_14.
Various methods for the chemical synthesis of gangliosides have been investigated to date and numerous natural gangliosides and their structural analogues have been synthesized during the past three decades. Key technologies in the synthesis of gangliosides include α-selective sialylation and introduction of the ceramide moiety into the oligosaccharide chain. This chapter introduces two major strategies for ganglioside synthesis-the most commonly used strategy and the recently developed glucosylceramide cassette approach. Synthetic procedures for selected reactions are also presented.
迄今为止，人们已经研究了多种神经节苷脂的化学合成方法，在过去三十年中已经合成了许多天然神经节苷脂及其结构类似物。神经节苷脂合成中的关键技术包括α-选择性唾液酸化以及将神经酰胺部分引入寡糖链。本章介绍了神经节苷脂合成的两种主要策略——最常用的策略和最近开发的葡萄糖神经酰胺盒式方法。还介绍了选定反应的合成步骤。
