福司可林：其对大鼠神经垂体中钾诱导的血管加压素释放的影响。
Forskolin: its effects on potassium-evoked release of vasopressin from the rat neurohypophysis.
作者信息
Bowman D, Hope D B
出版信息
Br J Pharmacol. 1985 May;85(1):197-203. doi: 10.1111/j.1476-5381.1985.tb08847.x.
The effect of forskolin, added either before or 5 min after the onset of potassium-evoked release of vasopressin from isolated neurointermediate lobes of the rat has been investigated. A low concentration of forskolin (1 microM), added before stimulation, enhanced the potassium-evoked release of vasopressin throughout two successive 5 min periods of stimulation. Higher concentrations of forskolin (10-80 microM) produced no effect on the potassium-evoked release of hormone during the first 5 min of stimulation, but inhibited release during the second 5 min period. When added 5 min after the onset of potassium stimulation, forskolin (1-80 microM) reduced the amount of vasopressin released during the remaining 5 min of stimulation. Forskolin produced a concentration-dependent increase in cyclic AMP during both the control and potassium stimulation periods. The amount of cyclic AMP generated by forskolin during potassium stimulation was less than that produced during the corresponding control periods.
已研究了福斯高林在钾诱发大鼠离体神经中间叶释放血管加压素之前或开始释放5分钟后添加时的作用。在刺激前添加低浓度的福斯高林（1微摩尔），在连续两个5分钟的刺激期内均增强了钾诱发的血管加压素释放。较高浓度的福斯高林（10 - 80微摩尔）在刺激的前5分钟对钾诱发的激素释放无影响，但在第二个5分钟期间抑制了释放。当在钾刺激开始5分钟后添加时，福斯高林（1 - 80微摩尔）减少了在剩余5分钟刺激期内释放的血管加压素量。在对照期和钾刺激期，福斯高林均使环磷酸腺苷产生浓度依赖性增加。钾刺激期间福斯高林产生的环磷酸腺苷量少于相应对照期产生的量。
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