Racké K, Rothländer M, Muscholl E
Eur J Pharmacol. 1982 Aug 13;82(1-2):97-100. doi: 10.1016/0014-2999(82)90560-x.
Isolated neurointermediate lobes of rat pituitaries were incubated in Krebs solution. The vasopressin release evoked by electrical stimulation (0.2 ms, 80 V, 15 Hz, 10 s trains at 10 s intervals for a total of 10 min) was completely inhibited by tetrodotoxin. Isoprenaline increased the evoked vasopressin release to a maximum of 60% (EC50 10 nM) and this effect was antagonized surmountably by propranolol. Forskolin increased the vasopressin release by 98%. These results suggest the presence within the neurohypophysis of a beta-adrenoceptor-linked adenylate cyclase facilitating vasopressin secretion.
将大鼠垂体的孤立神经中间叶置于 Krebs 溶液中进行孵育。电刺激（0.2 毫秒，80 伏，15 赫兹，每隔 10 秒进行 10 秒的刺激串，共持续 10 分钟）诱发的加压素释放被河豚毒素完全抑制。异丙肾上腺素可将诱发的加压素释放增加至最大 60%（半数有效浓度为 10 纳摩尔），且普萘洛尔可有效拮抗此效应。福斯高林使加压素释放增加了 98%。这些结果表明，神经垂体中存在一种与β-肾上腺素能受体相连的腺苷酸环化酶，可促进加压素分泌。
