Southampton Cancer Research UK Centre, University of Southampton, Southampton, UK.
Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK.
Cancer Med. 2018 Aug;7(8):3800-3811. doi: 10.1002/cam4.1594. Epub 2018 Jun 21.
Vacuolar ATPase (V-ATPase) is an ATP-dependent H -transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi-subunit protein complex and influences a wide range of cellular processes. This review focuses on emerging evidence for the roles for V-ATPase in cancer. This includes how V-ATPase dysregulation contributes to cancer growth, metastasis, invasion and proliferation, and the potential link between V-ATPase and the development of drug resistance.
液泡型 ATP 酶（V-ATPase）是一种依赖于 ATP 的 H + 转运体，可将质子泵入细胞内和质膜。它由一个大型多亚基蛋白复合物组成，并影响广泛的细胞过程。这篇综述重点介绍了 V-ATPase 在癌症中的作用的新证据。这包括 V-ATPase 失调如何促进癌症的生长、转移、侵袭和增殖，以及 V-ATPase 与耐药性发展之间的潜在联系。
