慢性给予阿米替林或米安色林对大鼠心脏和中枢肾上腺素能受体的影响。
Effects of chronic administration of amitriptyline or mianserin on rat cardiac and central adrenoceptors.
作者信息
Choudhury L, O'Donnell J M
出版信息
Br J Pharmacol. 1985 Jul;85(3):635-8. doi: 10.1111/j.1476-5381.1985.tb10558.x.
Abstract
Rats were administered either amitriptyline (20 mg kg-1, i.p.) or mianserin (10 mg kg-1, i.p.) for 21 consecutive days and the alpha- and beta-adrenoceptor characteristics of cardiac ventricles, cerebral cortex and hippocampus examined by ligand-binding procedure. Chronic administration of amitriptyline significantly reduced the maximum density of beta-receptors in the cerebral cortex without significantly altering cardiac alpha- or beta-receptors; mianserin treatment had no significant effect on any of the receptors studied.
摘要
给大鼠连续21天腹腔注射阿米替林（20毫克/千克）或米安色林（10毫克/千克），然后通过配体结合法检测心室、大脑皮层和海马体的α-和β-肾上腺素能受体特征。长期给予阿米替林可显著降低大脑皮层中β-受体的最大密度，而对心脏的α-或β-受体无显著影响；米安色林处理对所研究的任何受体均无显著影响。
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