蓝斑对海马刺激激活的伏隔核神经元的抑制作用。

Inhibition from locus coeruleus of nucleus accumbens neurons activated by hippocampal stimulation.

作者信息

Unemoto H, Sasa M, Takaori S

出版信息

Brain Res. 1985 Jul 15;338(2):376-9. doi: 10.1016/0006-8993(85)90172-6.

Abstract

Electrophysiological studies using rats were performed to examine the influence of locus coeruleus (LC) on nucleus accumbens (Acc) neurons. Spike generation by hippocampal stimulation was inhibited by both LC conditioning stimulation and iontophoretic application of noradrenaline, but spikes elicited by stimulation of parafascicular nucleus of thalamus were rarely affected by LC conditioning stimulation or noradrenaline. The LC-induced inhibition was antagonized by iontophoretic sotalol, but not by phentolamine, suggesting that noradrenaline derived from the LC inhibits the Acc neurons receiving input from the hippocampus, probably acting on a beta-adrenergic receptor.

摘要

利用大鼠进行电生理学研究，以检验蓝斑（LC）对伏隔核（Acc）神经元的影响。海马刺激引发的动作电位发放受到LC条件刺激和去甲肾上腺素离子导入的抑制，但丘脑束旁核刺激引发的动作电位很少受到LC条件刺激或去甲肾上腺素的影响。LC诱导的抑制作用可被索他洛尔离子导入拮抗，但不能被酚妥拉明拮抗，这表明源自LC的去甲肾上腺素抑制接受海马输入的Acc神经元，可能作用于β-肾上腺素能受体。