Leelathipkul Lalit, Tanticharoenwiwat Pattara, Ithiawatchakul Jutinan, Prommin Danu, Sirisalee Pasu, Junhunee Parinya, Poachanukoon Orapan
J Med Assoc Thai. 2016 Jul;99 Suppl 4:S265-74.
Inhaled bronchodilator treatment given via the pressurized metered-dose inhaler (pMDI) with spacer has been recommended for an acute asthma treatment. Unfortunately, most of commercially available spacers are at high cost while a do-it-yourself (DIY) spacer has lower cost as it is made from plastic bottle and siphon pump which are inexpensive and easilyfound materials.
This study aims to compare treatment response in nebulizer and DIY spacer used for asthmatic children.
A prospective, randomized control study was conducted in children aged 1-15 years old hospitalized for mild to moderate asthmatic attack at Thammasat University Hospital between June 2014 and March 2015. The patients were divided into 2 groups, receiving β2-agonist via nebulization and via pMDI with DIY spacer. Their vital signs and oxygen saturation were monitored and asthma scores were also recorded at admission, 24 hours, 48 hours, and before discharge. The satisfaction of equipment use was evaluated employing questionnaires.
40 childrens were enrolled with male at 72.5% and mean age at 3.1±1.6 years old. There was no significant difference in efficacy of β2-agonist among 2 groups when comparing in consideration of vital signs, oximetry, asthma scores and hospital stay. However, there were significantly different on side effect in which the DIY spacer had less tachycardia and agitation. Satisfaction of parents and healthcare workers were higher in DIY spacer.
MDI with DIY spacer was able to be used effectively when compared with nebulization to treat mild to moderate acute exacerbations of asthma in children admitted in hospital.
通过带有储雾罐的压力定量吸入器（pMDI）给予吸入性支气管扩张剂治疗已被推荐用于急性哮喘治疗。不幸的是，大多数市售储雾罐成本高昂，而自制（DIY）储雾罐成本较低，因为它由塑料瓶和虹吸泵制成，这些材料价格低廉且容易找到。
本研究旨在比较用于哮喘儿童的雾化器和自制储雾罐的治疗反应。
2014年6月至2015年3月期间，在泰国法政大学医院对1至15岁因轻度至中度哮喘发作住院的儿童进行了一项前瞻性随机对照研究。患者分为两组，分别通过雾化和使用自制储雾罐的pMDI接受β2激动剂治疗。监测他们的生命体征和血氧饱和度，并在入院时、24小时、48小时和出院前记录哮喘评分。采用问卷调查评估设备使用满意度。
共纳入40名儿童，男性占72.5%，平均年龄为3.1±1.6岁。在考虑生命体征、血氧饱和度、哮喘评分和住院时间时，两组之间β2激动剂的疗效无显著差异。然而，在副作用方面存在显著差异，自制储雾罐的心动过速和躁动较少。家长和医护人员对自制储雾罐的满意度更高。
与雾化相比，使用自制储雾罐的MDI能够有效治疗住院儿童的轻度至中度急性哮喘加重。
