Uaratanawong Rawipan, Uaratanawong Somchai, Chunhasewee Chakkrapong, Chawvavanich Prapawan
J Med Assoc Thai. 2016 Sep;99(9):1039-45.
Psoriasis vulgaris severity have been widely assessed by psoriasis area severity index (PASI) score. However, it may not be not the best measure because of the high variability and inability to tell the other aspect of the disease including co-morbidity and cardiovascular risk.
To determine the correlation between high sensitivity C-reactive protein (hs-CRP) level and psoriasis severity and to determine co-morbidities of psoriasis patients.
One hundred eighty psoriasis patients and thirty control patients were enrolled in the present cross-sectional study. Fasting venous blood were collected and analyzed for fasting plasma glucose, hemoglobin A1c, lipid profile, and hs-CRP. The psoriasis patients were assessed for skin severity by PASI scoring. The correlation was assessed by regression analysis.
The hs-CRP level was found significantly higher in the psoriasis group (p-value <0.001). The hs-CRP level significantly correlated with PASI score by using multivariate regression analysis.
This correlation between hs-CRP level and the psoriasis severity has led to the proposition that hs-CRP be used as a biomarker for overall inflammation including skin severity and cardiovascular risk factor in psoriasis.
寻常型银屑病的严重程度已通过银屑病面积和严重程度指数（PASI）评分进行广泛评估。然而，由于其高变异性以及无法反映该疾病的其他方面，包括合并症和心血管风险，它可能并非最佳衡量指标。
确定高敏C反应蛋白（hs-CRP）水平与银屑病严重程度之间的相关性，并确定银屑病患者的合并症。
本横断面研究纳入了180例银屑病患者和30例对照患者。采集空腹静脉血，分析空腹血糖、糖化血红蛋白、血脂谱和hs-CRP。通过PASI评分评估银屑病患者的皮肤严重程度。通过回归分析评估相关性。
银屑病组的hs-CRP水平显著更高（p值<0.001）。通过多变量回归分析，hs-CRP水平与PASI评分显著相关。
hs-CRP水平与银屑病严重程度之间的这种相关性促使人们提出，hs-CRP可作为银屑病中包括皮肤严重程度和心血管危险因素在内的整体炎症的生物标志物。
