Bhoi Anil Kumar, Grover Chander, Singal Archana, Kashyap Bineeta
Department of Dermatology and STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
Skin Appendage Disord. 2024 Dec;10(6):512-519. doi: 10.1159/000539150. Epub 2024 Jun 13.
Metabolic syndrome is a forerunner for adverse cardiovascular events. Its association with nail psoriasis has not been much explored. We conducted a cross-sectional study to investigate metabolic syndrome in patients with nail psoriasis as compared to psoriasis patients without nail involvement and healthy controls.
Thirty each adult participants with nail psoriasis (group-I), psoriasis without nail involvement (group-II) and healthy controls (group-III) were recruited. All participants were assessed for metabolic syndrome as per National Cholesterol Education Program-Adult Treatment Plan-III (NCEP-ATP-III) criteria. Disease severity assessment and serological assessment of high-sensitivity C-reactive protein (hsCRP) level was done.
Higher prevalence of metabolic syndrome was found in group-I compared to group-III (33.33 vs. 20%, = 0.420) with equal prevalence in group-I and group-II. Significantly higher prevalence of hypertension was seen in group-I and group-II ( = 0.036) as compared to group-III. Mean serum hsCRP was significantly higher for group-I as compared to group-II ( = 0.027) and group-III ( = 0.001). Weak positive correlation was seen between hsCRP levels and PASI and NAPSI scores.
Frequency of metabolic syndrome is similar in nail psoriasis patients and psoriasis patients without nail involvement. However, higher hsCRP levels with nail psoriasis may reflect increased risk of cardiovascular comorbidities. A baseline screening with correction of modifiable risk factors should be aimed at in patients with nail psoriasis.
代谢综合征是不良心血管事件的先兆。其与甲银屑病的关联尚未得到充分研究。我们进行了一项横断面研究，以调查甲银屑病患者与无甲受累的银屑病患者及健康对照者中的代谢综合征情况。
招募了30名成年甲银屑病患者（第一组）、无甲受累的银屑病患者（第二组）和健康对照者（第三组）。所有参与者均根据美国国家胆固醇教育计划成人治疗计划第三次报告（NCEP-ATP-III）标准进行代谢综合征评估。进行了疾病严重程度评估和高敏C反应蛋白（hsCRP）水平的血清学评估。
与第三组相比，第一组代谢综合征的患病率更高（33.33%对20%，P = 0.420），第一组和第二组患病率相同。与第三组相比，第一组和第二组高血压的患病率显著更高（P = 0.036）。与第二组（P = 0.027）和第三组（P = 0.001）相比，第一组的平均血清hsCRP显著更高。hsCRP水平与银屑病面积和严重程度指数（PASI）及甲银屑病面积和严重程度指数（NAPSI）评分之间存在弱正相关。
甲银屑病患者和无甲受累的银屑病患者中代谢综合征的发生率相似。然而，甲银屑病患者较高的hsCRP水平可能反映心血管合并症风险增加。对于甲银屑病患者，应进行基线筛查并纠正可改变的危险因素。
