短文：乙肝病毒感染已治愈患者中的丁型肝炎
Short article: Hepatitis delta in patients with resolved hepatitis B virus infection.
作者信息
Aguilera Antonio, Rodríguez-Calviño Javier, de Mendoza Carmen, Soriano Vincent
机构信息
Microbiology Department, Complexo Hospitalario Universitario Santiago (CHUS) and University of Santiago, Santiago de Compostela.
Laboratory of Internal Medicine, Puerta de Hierro Research Institute, Majadahonda.
出版信息
Eur J Gastroenterol Hepatol. 2018 Sep;30(9):1063-1065. doi: 10.1097/MEG.0000000000001187.
BACKGROUND
The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset shows elevated liver enzymes and hepatic fibrosis. Could they represent HBsAg-seronegative occult HDV infections?
METHODS
We tested for HDV-antibodies 406 individuals with markers of past HBV exposure.
RESULTS
Overall, 20 (4.9%) were reactive for HDV-antibodies. All were negative for serum HDV-RNA, including four with elevated liver enzymes.
CONCLUSION
These results support the current policy of screening for hepatitis delta only in HBsAg+ individuals.
背景
丁型肝炎病毒（HDV）可引发最具侵袭性的慢性病毒性肝炎。由于HDV复制需要乙型肝炎病毒（HBV），HDV筛查仅限于HBsAg阳性携带者。迄今为止，具有HDV抗体且有乙型肝炎康复标志物的个体被认为已治愈。然而，有一部分人肝酶升高且存在肝纤维化。他们是否代表HBsAg血清学阴性隐匿性HDV感染？
方法
我们对406名有既往HBV暴露标志物的个体进行了HDV抗体检测。
结果
总体而言，20名（4.9%）个体HDV抗体呈阳性反应。所有个体血清HDV-RNA均为阴性，其中4名肝酶升高。
结论
这些结果支持目前仅对HBsAg阳性个体进行丁型肝炎筛查的政策。
Zotero 插件