无症状丁型肝炎病毒（HDV）感染病例中HDV-RNA的测定。

Determination of hepatitis delta virus (HDV)-RNA in asymptomatic cases of HDV infection.

作者信息

Sakugawa H, Nakasone H, Kawakami Y, Adaniya H, Mizushima T, Nakayoshi T, Kinjo F, Saito A, Zukeran H, Miyagi Y, Yakabi S, Taira M, Kinoshita M, Yamakawa Y

机构信息

First Department of Internal Medicine, Faculty of Medicine, University of the Ryukus, Okinawa Prefectural Miyako Hospital, Japan.

出版信息

Am J Gastroenterol. 1997 Dec;92(12):2232-6.

PMID:9399760

Abstract

OBJECTIVES

To assess the frequency of hepatitis delta virus (HDV) viremia in asymptomatic cases of HDV infection and the clinical significance of the HDV viremia, we conducted a cross-sectional, community-based study.

METHODS

Of 2207 examinees, 210 (9.5%) were found to be positive for hepatitis B surface antigen (HBsAg). Antibody to HDV was detected in 47 (22.4%) of the 210 examinees, and 43 of the 47 were further evaluated for serum HDV-RNA by polymerase chain reaction.

RESULTS

Twenty-one (48.8%) of the 43 had detectable levels of HDV-RNA in serum, and 22 (51.2%) were negative for serum HDV-RNA. The majority (61.9%) of the HDV-RNA-positive HBsAg carriers had high levels of serum ALT. In contrast, the frequency of an abnormally high level of serum ALT was only 9.1% in the HBsAg carriers positive for HDV antibody but negative for HDV-RNA, and the frequency did not differ from that seen in the HBsAg-negative individuals. The semiquantified HDV-RNA levels did not correlate with the serum ALT levels.

CONCLUSION

Seropositivity of HDV-RNA was strongly associated with liver cell damage, even in asymptomatic cases. The absence of a detectable level of serum HDV-RNA might be related to previous HDV infection.

摘要

目的

为评估无症状丁型肝炎病毒（HDV）感染病例中HDV病毒血症的发生率以及HDV病毒血症的临床意义，我们开展了一项基于社区的横断面研究。

方法

在2207名受检者中，210名（9.5%）乙型肝炎表面抗原（HBsAg）检测呈阳性。在这210名受检者中，47名（22.4%）检测出HDV抗体，其中43名进一步通过聚合酶链反应评估血清HDV-RNA。

结果

43名受检者中有21名（48.8%）血清HDV-RNA水平可检测到，22名（51.2%）血清HDV-RNA呈阴性。大多数（61.9%）HDV-RNA阳性的HBsAg携带者血清ALT水平较高。相比之下，HDV抗体阳性但HDV-RNA阴性的HBsAg携带者中，血清ALT异常高水平的发生率仅为9.1%，且该发生率与HBsAg阴性个体无差异。HDV-RNA的半定量水平与血清ALT水平无关。