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Immune reactivity to Thomsen-Friedenreich antigen in patients with lung cancer detected by superoxide assay-leukocyte adherence inhibition test.

作者信息

Ichinose Y, Yagawa K, Kaku M, Hara N, Ohta M

出版信息

Cancer Res. 1985 Sep;45(9):4473-7.

PMID:2992780
Abstract

The immune reactivity to partially purified Thomsen-Friedenreich antigen was investigated in patients with lung cancer. The modified method of original leukocyte adherence inhibition test, termed superoxide assay-leukocyte adherence inhibition test, was used to detect the reactivity. The coded peripheral mononuclear cells from 34 of 50 (68%) patients with lung cancer showed a positive response to the antigen whereas in only 3 of 19 (16%) patients with benign pulmonary disease was there a reaction to the antigen. The same experiments were performed using the 3 m KCl extract of lung tumors as an antigen. In this case in 39 of 50 (78%) patients with lung cancer but in only 4 of 24 (17%) with benign pulmonary disease and in none of the breast cancer patients (0 of 17) was there a reaction to the antigen. These results strongly suggest that patients with lung cancer are sensitized to both Thomsen-Friedenreich antigen and tumor-associated antigens expressed in cancer cells of lung tissue origin.

摘要

相似文献

1
Immune reactivity to Thomsen-Friedenreich antigen in patients with lung cancer detected by superoxide assay-leukocyte adherence inhibition test.
Cancer Res. 1985 Sep;45(9):4473-7.
2
Superoxide assay-leukocyte adherence inhibition test and a soluble factor which stimulates the adherence of macrophages.超氧化物测定-白细胞黏附抑制试验以及一种刺激巨噬细胞黏附的可溶性因子。
Cancer Res. 1980 Dec;40(12):4791-5.
3
[Study on the tumor immunity of renal cell carcinoma--with special reference to the significance of leukocyte adherence inhibition test].
Hinyokika Kiyo. 1984 Oct;30(10):1367-77.
4
Specificity of tumor antigen recognition by T-lymphocytes in the leukocyte adherence inhibition (LAI) assay in patients with breast cancer.乳腺癌患者白细胞黏附抑制(LAI)试验中T淋巴细胞对肿瘤抗原识别的特异性
J Clin Lab Immunol. 1982 Dec;9(3):151-7.
5
Human lung carcinoma monoclonal antibody specific for the Thomsen-Friedenreich antigen.对桑福德-弗里德赖希抗原具有特异性的人肺癌单克隆抗体。
Cancer Res. 1989 Jan 1;49(1):32-7.
6
Humoral antitumor immune responses in patients with breast cancer measured with the leukocyte adherence inhibition technique.采用白细胞黏附抑制技术检测乳腺癌患者的体液抗肿瘤免疫反应。
J Natl Cancer Inst. 1981 Feb;66(2):265-71.
7
Indirect leukocyte migration inhibition reactions to a 3-M KCl extract of lung adenocarcinoma by lung cancer patients.肺癌患者对肺腺癌3-M KCl提取物的间接白细胞迁移抑制反应。
J Natl Cancer Inst. 1981 Feb;66(2):233-7.
8
Humoral leukocyte adherence inhibition (H-LAI) test in screening of high risk group for lung cancer.体液白细胞黏附抑制(H-LAI)试验在肺癌高危人群筛查中的应用
Neoplasma. 1990;37(2):173-8.
9
[Thomsen antigen in human normal and tumor tissues].
Biull Eksp Biol Med. 1983 Mar;95(3):59-61.
10
[Determination of antigen-dependent activity of human lung cancer transfer factor by H3-leucine leucine leukocyte adherence inhibition assay].[用³H-亮氨酸白细胞黏附抑制试验测定人肺癌转移因子的抗原依赖性活性]
Zhonghua Zhong Liu Za Zhi. 1992 Mar;14(2):116-8.

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