Li Chuanyin, Wang Xiaona, Li Yingfu, Zhang Xinwen, Sun Mingbo, Liu Shuyuan, Sun Le, Shi Li, Yao Yufeng
Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China.
Department of Geriatrics, The No.1 Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Cancer Manag Res. 2018 Jun 11;10:1487-1495. doi: 10.2147/CMAR.S166235. eCollection 2018.
Recent studies have revealed that the gene plays crucial roles in cancer initiation and development. Genome-wide analysis studies and case-control studies have demonstrated that polymorphisms in the gene are associated with various cancers.
In the current study, we analyzed the associations of eight single nucleotide polymorphisms (SNPs) in the gene with non-small cell lung cancer (NSCLC) in a Chinese Han population. A total of 467 NSCLC patients and 526 healthy individuals were recruited for SNP genotyping using a TaqMan assay.
Our results revealed that the allelic frequencies of rs2853677 and rs2853691 were significantly different between the NSCLC and control groups (=0.004 and 0.001, respectively). Moreover, the T allele of rs2853677 and the A allele of rs2853691 might be the protective factors against NSCLC (OR=0.766; 95%CI: 0.639-0.918 and OR=0.714; 95%CI: 0.584-0.875, respectively). Additionally, stratified association analysis of the eight SNPs with the different pathological NSCLC stages (I+II and III+IV) and different pathological types (adenocarcinoma and squamous cell carcinoma) revealed that none of the SNPs were significantly different between patients with different pathological stages and pathological types.
Our results indicated that rs2853677 and rs2853691 in the gene might be associated with NSCLC in this Chinese Han population.
近期研究表明，该基因在癌症的发生和发展中起关键作用。全基因组分析研究和病例对照研究已证明，该基因的多态性与多种癌症相关。
在本研究中，我们分析了该基因的8个单核苷酸多态性（SNP）与中国汉族人群非小细胞肺癌（NSCLC）的相关性。共招募了467例NSCLC患者和526名健康个体，采用TaqMan分析法进行SNP基因分型。
我们的结果显示，NSCLC组和对照组之间rs2853677和rs2853691的等位基因频率存在显著差异（分别为=0.004和0.001）。此外，rs2853677的T等位基因和rs2853691的A等位基因可能是NSCLC的保护因素（OR=0.766；95%CI：0.639 - 0.918和OR=0.714；95%CI：0.584 - 0.875）。此外，对这8个SNP与不同病理NSCLC分期（I + II和III + IV）以及不同病理类型（腺癌和鳞状细胞癌）进行分层关联分析，结果显示不同病理分期和病理类型的患者之间，所有SNP均无显著差异。
我们的结果表明，该基因中的rs2853677和rs2853691可能与中国汉族人群的NSCLC相关。
