Rustin G J, Bagshawe K D
Crit Rev Oncol Hematol. 1985;3(2):103-42. doi: 10.1016/s1040-8428(85)80022-6.
Although virtually 100% of women who develop gestational trophoblastic tumors enter a long-term complete remission, there are many aspects of trophoblastic disease that arouse interest. Epidemiological studies have shown a large geographical variation in the percentage of conceptions that result in a hydatidiform mole and have stimulated studies on the immunological differences of the low and high risk populations. Chromosomal analysis is now complementing the pathological differentiation between complete and partial moles. There is still debate as to which factors are positively associated with the progression of a hydatidiform mole through invasive mole to choriocarcinoma. There are also considerable differences in the proportion of molar patients receiving chemotherapy in different centers. In addition to these topics, this article will review several recently introduced treatment regimens which show improved results with reduced toxicity.
尽管几乎100%患有妊娠滋养细胞肿瘤的女性都能实现长期完全缓解，但滋养细胞疾病仍有许多方面引发人们的兴趣。流行病学研究表明，导致葡萄胎的妊娠百分比在地域上存在很大差异，这激发了对低风险和高风险人群免疫差异的研究。染色体分析目前正在补充完全性和部分性葡萄胎之间的病理鉴别。关于哪些因素与葡萄胎通过侵蚀性葡萄胎发展为绒毛膜癌呈正相关仍存在争议。不同中心接受化疗的葡萄胎患者比例也存在相当大的差异。除了这些主题，本文还将回顾几种最近引入的治疗方案，这些方案显示出疗效改善且毒性降低。
