Cruz Michelle S, Diamond Alani, Russell Astrid, Jameson Julie Marie
Department of Biological Sciences, California State University of San Marcos, San Marcos, CA, United States.
Front Immunol. 2018 Jun 6;9:1304. doi: 10.3389/fimmu.2018.01304. eCollection 2018.
γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident T cell function can aggravate skin-related autoimmune diseases, impede tumor eradication, or disrupt proper wound healing. Much of the published work on human skin T cells attributes T cell function in the skin to αβ T cells, while γδ T cells are an often overlooked participant. This review details the roles played by both αβ and γδ T cells in healthy human skin and then focuses on their roles in skin diseases, such as psoriasis and alopecia areata. Understanding the contribution of skin-resident and skin-infiltrating T cell populations and cross-talk with other immune cells is leading to the development of novel therapeutics for patients. However, there is still much to be learned in order to effectively modulate T cell function and maintain healthy skin homeostasis.
γδ T淋巴细胞通过平衡角质形成细胞的分化和增殖与对受感染或恶性细胞的破坏来维持皮肤稳态。皮肤驻留T细胞功能的失衡会加重与皮肤相关的自身免疫性疾病、阻碍肿瘤根除或破坏正常的伤口愈合。关于人类皮肤T细胞的许多已发表研究将皮肤中的T细胞功能归因于αβ T细胞，而γδ T细胞则常常被忽视。这篇综述详细阐述了αβ和γδ T细胞在健康人类皮肤中所起的作用，然后重点关注它们在银屑病和斑秃等皮肤病中的作用。了解皮肤驻留和皮肤浸润T细胞群体的贡献以及与其他免疫细胞的相互作用正在推动针对患者的新型疗法的开发。然而，为了有效调节T细胞功能并维持健康的皮肤稳态，仍有许多需要学习的地方。
