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人乳头瘤病毒16型E7蛋白增加环氧化酶-2的表达并促进乳腺癌的增殖。

HPV16 E7 increases COX-2 expression and promotes the proliferation of breast cancer.

作者信息

Wang Yong-Xia, Zhang Zhe-Ying, Wang Jian-Qiang, Qian Xin-Lai, Cui Jing

机构信息

Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.

Department of Pathology, Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.

出版信息

Oncol Lett. 2018 Jul;16(1):317-325. doi: 10.3892/ol.2018.8624. Epub 2018 May 3.

DOI:10.3892/ol.2018.8624
PMID:29928417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6006466/
Abstract

Breast cancer remains the leading cause of mortality worldwide. Human papilloma virus 16 (HPV16) may serve a function in the pathogenesis and development of breast cancer. However, the detection rate of HPV16 in breast carcinoma may vary by region. In the present study, the expression of HPV16 E7 in paraffin-embedded tissues from patients with breast cancer from North China was detected. Additionally, the molecular mechanisms underlying the function of HPV16 E7 in the proliferation of breast cancer cells were examined. The results demonstrated that the DNA of HPV16 E7 was detected in 30.5% of the samples, and that HPV16 E7 promoted the proliferation of breast cancer cells and . Additionally, HPV16 E7-mediated proliferation of breast cancer cells was suppressed in response to treatment with cyclooxygenase-2 (COX-2)-specific small interfering RNA and celecoxib. The results of the present study revealed that HPV16 E7 may promote the proliferation of breast cancer cells by upregulating COX-2, suggesting that COX-2 may be a potential therapeutic target for HPV16 E7-mediated progression of breast cancer.

摘要

乳腺癌仍然是全球范围内导致死亡的主要原因。人乳头瘤病毒16型（HPV16）可能在乳腺癌的发病机制和发展过程中发挥作用。然而，乳腺癌中HPV16的检出率可能因地区而异。在本研究中，检测了来自中国北方乳腺癌患者石蜡包埋组织中HPV16 E7的表达。此外，还研究了HPV16 E7在乳腺癌细胞增殖中发挥作用的分子机制。结果表明，30.5%的样本中检测到HPV16 E7的DNA，且HPV16 E7促进了乳腺癌细胞的增殖。此外，环氧合酶-2（COX-2）特异性小干扰RNA和塞来昔布处理可抑制HPV16 E7介导的乳腺癌细胞增殖。本研究结果显示，HPV16 E7可能通过上调COX-2促进乳腺癌细胞增殖，提示COX-2可能是HPV16 E7介导的乳腺癌进展的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a67/6006466/54e77c1b60b9/ol-16-01-0317-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a67/6006466/037ec97d2f99/ol-16-01-0317-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a67/6006466/7a1be1a26591/ol-16-01-0317-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a67/6006466/54e77c1b60b9/ol-16-01-0317-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a67/6006466/037ec97d2f99/ol-16-01-0317-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a67/6006466/7a1be1a26591/ol-16-01-0317-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a67/6006466/54e77c1b60b9/ol-16-01-0317-g02.jpg

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