与两种抗体相关的自身免疫性脑炎。

Autoimmune encephalitis associated with two antibodies.

作者信息

Reyes Nikolai Gil D, Prado Mario B, Turalde Christian Wilson R, Fernandez Marc Laurence L

机构信息

Department of Neurosciences, College of Medicine-Philippine General Hospital, University of the Philippines Manila, Taft Avenue, Manila, Philippines.

出版信息

Epilepsy Behav Case Rep. 2018 Apr 18;10:44-46. doi: 10.1016/j.ebcr.2018.04.001. eCollection 2018.

DOI:10.1016/j.ebcr.2018.04.001

PMID:29928585

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6008288/

Abstract

•In patients presenting with clinical manifestations of encephalitis without clinical or laboratory signs of infection, an autoimmune etiology should be suspected.•Antibodies for various neural antigens may coexist, thus a complete and clinically-guided autoimmune panel must be done in suspected cases of autoimmune encephalitis.•Tumor resection, if applicable, combined with high dose steroids and immunotherapy are effective treatment strategies for autoimmune encephalitis with coexisting antibodies.

摘要

•在出现脑炎临床表现但无临床或实验室感染迹象的患者中，应怀疑自身免疫性病因。

•各种神经抗原的抗体可能同时存在，因此在疑似自身免疫性脑炎病例中必须进行完整且由临床指导的自身免疫检测项目。

•如有可能，肿瘤切除联合大剂量类固醇和免疫疗法是针对伴有共存抗体的自身免疫性脑炎的有效治疗策略。