Rigby Simon W, Johnson Leigh F
Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.
Infect Dis Model. 2017 Feb 16;2(1):71-89. doi: 10.1016/j.idm.2017.02.002. eCollection 2017 Feb.
Many studies have shown that women who have experienced intimate partner violence (IPV) are at a greater risk of HIV, but the factors accounting for this association are unclear, and trials of interventions to reduce IPV have not consistently reduced HIV incidence.
This study uses an agent-based model, calibrated to South African data sources, to evaluate hypotheses about likely causal pathways linking IPV, HIV, and other confounding factors. Assumptions about associations between IPV and HIV risk behaviours were based on reviews of international literature.
There is an association between past IPV experience and HIV incidence even when no causal effects are assumed (IRR 1.28, 95% CI 1.23-1.34), because women with a propensity for multiple partners are more likely to have ever been in a relationship with a violent partner. If, in addition, men with a propensity for concurrent relationships are more likely to perpetrate IPV, the IRR increases to 1.42 (95% CI 1.36-1.48), consistent with empirical IRR estimates. Alternative scenarios in which experience of IPV is assumed to cause changes in women's sexual behaviour have little effect on the IRR. An intervention that reduces IPV by 50% could be expected to reduce HIV incidence by at most 1.3%.
Much of the observed association between IPV and HIV is likely to be due to confounding behavioural factors. Although interventions to reduce IPV are important, these interventions alone are unlikely to have a substantial impact on HIV incidence.
许多研究表明,遭受亲密伴侣暴力(IPV)的女性感染艾滋病毒的风险更高,但导致这种关联的因素尚不清楚,而且减少IPV的干预试验并未持续降低艾滋病毒发病率。
本研究使用基于主体的模型,根据南非数据源进行校准,以评估关于IPV、艾滋病毒和其他混杂因素之间可能因果途径的假设。关于IPV与艾滋病毒风险行为之间关联的假设基于对国际文献的综述。
即使不假设存在因果效应,过去的IPV经历与艾滋病毒发病率之间也存在关联(发病率比[IRR]为1.28,95%置信区间[CI]为1.23 - 1.34),因为有多伴侣倾向的女性更有可能曾与暴力伴侣建立关系。此外,如果有同时存在多个性伴侣倾向的男性更有可能实施IPV,IRR会增加到1.42(95% CI为1.36 - 1.48),这与实证IRR估计值一致。假设IPV经历会导致女性性行为发生变化的其他情景对IRR影响不大。一项将IPV减少50%的干预措施预计最多可将艾滋病毒发病率降低1.3%。
IPV与艾滋病毒之间观察到的大部分关联可能归因于混杂的行为因素。虽然减少IPV的干预措施很重要,但仅靠这些干预措施不太可能对艾滋病毒发病率产生实质性影响。