Department of Pharmacy, College of Medicine, Jianghan University, Wuhan 430056, People's Republic of China.
Department of Pharmacy, College of Medicine, Jianghan University, Wuhan 430056, People's Republic of China.
Fitoterapia. 2018 Sep;129:42-46. doi: 10.1016/j.fitote.2018.06.014. Epub 2018 Jun 19.
A novel sesquilignan compound (1), possesing an unusual carbon skeleton of aryltetralin unit linked with a C6-C3 unit and a five-membered ring by a C-7″ and C-4 linkage pattern via an oxygen atom, and a new lignan glycoside (2) have been isolated from the twigs and leaves of Illicium majus. Their structures were determined by spectroscopic analysis and chemical methods. The absolute configurations of 1 and 2 are confirmed by observing the circular dichroism. At 10 μM, Compounds 1 and 2 showed in Vitro inhibitory activity against the release of β-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor.
从八角属植物 Illicium majus 的嫩枝和叶片中分离得到一个新的倍半木脂素化合物（1），具有芳基四氢萘单元与 C6-C3 单元通过 C-7″和 C-4 键合模式连接的不寻常碳骨架，以及一个五员环通过一个氧原子，和一个新的木脂素糖苷（2）。它们的结构通过光谱分析和化学方法确定。通过观察圆二色性，确定了 1 和 2 的绝对构型。在 10μM 时，化合物 1 和 2 对血小板激活因子诱导的大鼠多形核白细胞β-葡萄糖醛酸酶释放表现出体外抑制活性。
