State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Planta Med. 2013 Jan;79(2):142-9. doi: 10.1055/s-0032-1328056. Epub 2012 Dec 18.
Four new abietane diterpenes (1-4) and two new cycloparvifloralone-type sesquiterpenoids (5-6) have been isolated from the twigs and leaves of Illicium majus, together with three known sesquiterpenoids and five known diterpenoids. Their structures were determined by spectroscopic analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 2 is confirmed by Snatzke's method, observing the induced circular dichroism after the addition of dimolybdenum tetraacetate in DMSO. Compound 2 exihibited significant anti-inflammatory activity with an IC50 value of 0.26 ± 0.03 µM, while compounds 10, 11, and 13 showed good anti-inflammatory activities with IC50 values ranging from 1.94 ± 0.56 to 2.60 ± 0.48 µM.
从八角属植物 Illicium majus 的小枝和叶中分离得到了四个新的扁柏烷二萜（1-4）和两个新的环杷夫酮型倍半萜（5-6），以及三个已知的倍半萜和五个已知的二萜。通过光谱分析和化学方法确定了它们的结构。通过 Snatzke 法，观察到二钼四醋酸酯在 DMSO 中加入后产生的诱导圆二色性，确定了 2 中 15,16-二醇部分的绝对构型。化合物 2 表现出显著的抗炎活性，IC50 值为 0.26±0.03µM，而化合物 10、11 和 13 表现出良好的抗炎活性，IC50 值在 1.94±0.56 至 2.60±0.48µM 之间。
