Department of Respiratory Medicine, Linyi Central Hospital, No. 17 Jiankang Road, 276400 Linyi, China.
Department of Respiratory Medicine, Linyi Central Hospital, No. 17 Jiankang Road, 276400 Linyi, China.
Fitoterapia. 2018 Sep;129:73-77. doi: 10.1016/j.fitote.2018.06.011. Epub 2018 Jun 18.
Guajadial, one of natural dialdehyde meroterpenoids, demonstrated significant antineoplasmic activity. The present research was to investigate the inhibitory effects of guajadial by using two NSCLC cells (A549 and H1650) proliferation and migration. Western blotting was employed to explore the underlying mechanisms of VEGF receptor (VEGFR)2-mediated. This research indicated that guajadial not only inhibited endothelial cell proliferation and migration but also suppress tumor growth in human NSCLC xenograft mouse models. It is also suggested that guajadial inhibited A549 proliferation via blocking the Ras/MAPK pathway.
瓜达醛是一种天然的二醛倍半萜类化合物，具有显著的抗肿瘤活性。本研究旨在通过两种非小细胞肺癌细胞（A549 和 H1650）的增殖和迁移实验来研究瓜达醛的抑制作用。Western blot 被用来探索血管内皮生长因子受体（VEGFR）2 介导的潜在机制。研究表明，瓜达醛不仅抑制内皮细胞的增殖和迁移，而且还能抑制人非小细胞肺癌异种移植小鼠模型中的肿瘤生长。此外，研究还表明，瓜达醛通过阻断 Ras/MAPK 通路抑制 A549 的增殖。
