Ibrahim Iman, Zeitouni Anthony, da Silva Sabrina Daniela
Audiol Neurootol. 2018;23(1):1-7. doi: 10.1159/000486274. Epub 2018 Jun 22.
Sudden sensorineural hearing loss (SSNHL) is an otological emergency of unknown etiology. Recent reports showed that antioxidant drugs can benefit patients with SSNHL. This study attempted to evaluate the effect of adding antioxidant vitamins as an adjuvant therapy alongside with corticosteroids.
To evaluate the effects of the 3 major antioxidant vitamins (A, C, and E) as an adjuvant therapy, administered with corticosteroids, for the treatment of SSNHL in adult patients (≥18 years).
MEDLINE, EMBASE, PubMed, Web of Science and Cochrane electronic databases from January 1, 1995, through September 25, 2017.
Published studies of adult patients who received antioxidant vitamins (A, C, E, or any combination of these vitamins) as an adjuvant therapy in addition to the regular treatment (corticosteroids) for SSNHL. Quality assessment was performed using the Cochrane Collaboration Tool for Assessing Risk of Bias.
Each study had a control group (conventional treatment + placebo) and a trial group (antioxidant vitamin(s) + conventional treatment).
From 446 manuscripts identified in the literature, 3 studies were included in the review with 279 patients. The most common vitamins used to treat SSNHL were the 3 major antioxidant vitamins A, C, and E, combined sometimes with other antioxidants such as selenium.
The success of the treatment is increased in patients who received antioxidant vitamins in combination with conventional therapy.
突发性感音神经性听力损失（SSNHL）是一种病因不明的耳科急症。近期报告显示抗氧化药物对SSNHL患者有益。本研究试图评估添加抗氧化维生素作为皮质类固醇辅助治疗的效果。
评估三种主要抗氧化维生素（A、C和E）作为辅助治疗与皮质类固醇联合使用对成年患者（≥18岁）SSNHL的治疗效果。
1995年1月1日至2017年9月25日期间的MEDLINE、EMBASE、PubMed、科学网和考科蓝电子数据库。
已发表的关于成年患者的研究，这些患者除了接受SSNHL的常规治疗（皮质类固醇）外，还接受了抗氧化维生素（A、C、E或这些维生素的任何组合）作为辅助治疗。使用考科蓝协作偏倚风险评估工具进行质量评估。
每项研究都有一个对照组（常规治疗+安慰剂）和一个试验组（抗氧化维生素+常规治疗）。
从文献中识别出的446篇手稿中，有3项研究纳入综述，涉及279例患者。用于治疗SSNHL最常用的维生素是三种主要抗氧化维生素A、C和E，有时还与其他抗氧化剂如硒联合使用。
接受抗氧化维生素与常规治疗联合使用的患者治疗成功率提高。
