Hur Yoon-Mi, Choi Eun-Ji, Kim Jong-Woo, Jin Hee-Jeong, Lee Siwoo
Research Institute for the Welfare Society,Mokpo National University,Jeonnam,South Korea.
Department of Neuropsychiatry,Kyung Hee University,Seoul,South Korea.
Twin Res Hum Genet. 2018 Oct;21(5):378-383. doi: 10.1017/thg.2018.40. Epub 2018 Jun 22.
The present study aimed to estimate heritability of Hwabyung (HB) symptoms in adolescent and young adult twins in South Korea. The sample included 1,601 twins consisting of 143 pairs of monozygotic male (MZM), 67 pairs of dizygotic male (DZM), 295 pairs of monozygotic female (MZF), 114 pairs of dizygotic female (DZF), and 117 pairs of opposite-sex dizygotic (OSDZ) twins and 129 twins with non-participating co-twins (mean age = 19.1 ± 3.1 years; range: 12-29 years). An HB symptom questionnaire was given to twins via a telephone interview. Consistent with the literature of HB, the mean level of HB was significantly higher in females than in males. Maximum likelihood twin correlations for HB were 0.31 (95% CI [0.16, 0.45]) for MZM, 0.19 (95% CI [-0.05, 0.41]) for DZM, 0.50 (95% CI [0.41, 0.58]) for MZF, 0.28 (95% CI [0.11, 0.44]) for DZF, and 0.23 (95% CI [0.05, 0.40]) for OSDZ twins. These patterns of twin correlations suggested the presence of additive genetic influences on HB. Model-fitting analysis showed that additive genetic and individual-specific environmental influences on HB were 44% (95% CI [37, 51]) and 56% (95% CI [49, 63]), respectively. Shared environmental influences were not significant. These parameter estimates were not significantly different between two sexes, and did not change significantly with age in the present sample, suggesting that genetic and environmental influences on HB in both sexes are stable across adolescence and young adulthood.
本研究旨在估计韩国青少年和青年双胞胎中“火病”（HB）症状的遗传度。样本包括1601对双胞胎，其中有143对同卵男性双胞胎（MZM）、67对异卵男性双胞胎（DZM）、295对同卵女性双胞胎（MZF）、114对异卵女性双胞胎（DZF）、117对异性异卵双胞胎（OSDZ）以及129对有未参与的孪生同胞的双胞胎（平均年龄 = 19.1 ± 3.1岁；范围：12 - 29岁）。通过电话访谈向双胞胎发放了一份HB症状问卷。与HB的文献一致，女性的HB平均水平显著高于男性。MZM的HB最大似然双胞胎相关性为0.31（95%置信区间[0.16, 0.45]），DZM为0.19（95%置信区间[-0.05, 0.41]），MZF为0.50（95%置信区间[0.41, 0.58]），DZF为0.28（95%置信区间[0.11, 0.44]），OSDZ双胞胎为0.23（95%置信区间[0.05, 0.40]）。这些双胞胎相关性模式表明存在对HB的加性遗传影响。模型拟合分析表明，对HB的加性遗传和个体特异性环境影响分别为44%（95%置信区间[37, 51]）和56%（95%置信区间[49, 63]）。共同环境影响不显著。这些参数估计在两性之间没有显著差异，并且在本样本中随年龄没有显著变化，这表明两性中对HB的遗传和环境影响在整个青春期和青年期都是稳定的。
