Hur Yoon-Mi, Yu Hana, Jin Hee-Jeong, Lee Siwoo
Research Institute for Welfare Society,Mokpo National University,Jeonnam,South Korea.
Mibyeong Research Center,Korea Institute of Oriental Medicine,Daejeon,South Korea.
Twin Res Hum Genet. 2018 Jun;21(3):227-232. doi: 10.1017/thg.2018.17. Epub 2018 Apr 12.
In traditional East Asian medicine, cold-heat patterns have been widely used in the diagnosis and treatment of patients suffering from various diseases. The present study aimed to estimate the heritability of cold-heat patterns. Trained interviewers administered a cold-heat pattern questionnaire to 1,753 twins (mean age = 19.1 ± 3.1 years) recruited throughout South Korea. Correlations for the cold pattern (CP) were 0.42 (95% CI [0.28, 0.54]) for monozygotic (MZ) males, 0.16 (95% CI [-0.08, 0.39]) for dizygotic (DZ) males, 0.40 (95% CI [0.30, 0.49]) for MZ females, 0.30 (95% CI [0.12, 0.45]) for DZ females, and 0.07 (95% CI [-0.11, 0.25]) for opposite-sex DZ twins. The corresponding twin correlations for the heat pattern (HP) were 0.38 (95% CI [0.24, 0.51]), -0.22 (95% CI [-0.43, 0.02]), 0.34 (95% CI [0.24, 0.43]), 0.21 (95% CI [0.03, 0.37]), and 0.08 (95% CI [-0.10, 0.26]), respectively. These patterns of twin correlations suggested significant genetic effects on the HP and the CP. Model-fitting analysis revealed that heritability estimates in both sexes were 40% (95% CI [38, 42]) for the CP and 33% (95% CI [25, 42]) for the HP, with the remaining variances attributable to unique environmental variances. These estimates did not vary significantly with age during adolescence and young adulthood.
在传统东亚医学中，寒热证型已被广泛应用于各类疾病患者的诊断和治疗。本研究旨在评估寒热证型的遗传度。训练有素的访谈者对在韩国各地招募的1753对双胞胎（平均年龄 = 19.1 ± 3.1岁）进行了寒热证型问卷调查。单卵（MZ）男性的寒证型（CP）相关性为0.42（95%可信区间[0.28, 0.54]），双卵（DZ）男性为0.16（95%可信区间[-0.08, 0.39]），MZ女性为0.40（95%可信区间[0.30, 0.49]），DZ女性为0.30（95%可信区间[0.12, 0.45]），异性DZ双胞胎为0.07（95%可信区间[-0.11, 0.25]）。热证型（HP）的相应双胞胎相关性分别为0.38（95%可信区间[0.24, 0.51]）、-0.22（95%可信区间[-0.43, 0.02]）、0.34（95%可信区间[0.24, 0.43]）、0.21（95%可信区间[0.03, 0.37]）和0.08（95%可信区间[-0.10, 0.26]）。这些双胞胎相关性模式表明，遗传因素对HP和CP有显著影响。模型拟合分析显示，CP在两性中的遗传度估计值均为40%（95%可信区间[38, 42]），HP为33%（95%可信区间[25, 42]），其余方差归因于独特环境方差。在青春期和青年期，这些估计值随年龄变化不显著。
