Cao Taige, Tey Hong Liang, Yosipovitch Gil
National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore.
National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore 308232, Singapore.
Dermatol Clin. 2018 Jul;36(3):199-211. doi: 10.1016/j.det.2018.02.004. Epub 2018 Mar 20.
Chronic pruritus (>6 week's duration) in the geriatric population (≥65 years old), is an increasing health care problem. The pathophysiologic predisposing factors are abnormalities of the epidermal barrier, immune system, and nervous system. Causes can be dichotomized into histaminergic and nonhistaminergic pruritus. Topical treatments are generally safe. Systemic treatments are chosen depending on the condition, comorbid diseases, and drug interactions. Treatment options are limited. Progress has been made in identifying itch-selective mediators over the last decade. Numerous new medications are currently undergoing clinical trials and they are anticipated to enter the clinics in the near future.
老年人群（≥65岁）中的慢性瘙痒（持续时间>6周）是一个日益严重的医疗保健问题。病理生理易感因素包括表皮屏障、免疫系统和神经系统异常。病因可分为组胺能性和非组胺能性瘙痒。局部治疗通常是安全的。全身治疗根据病情、合并疾病和药物相互作用来选择。治疗选择有限。在过去十年中，在确定瘙痒选择性介质方面取得了进展。目前有许多新药正在进行临床试验，预计在不久的将来进入临床应用。
