Reszke Radomir, Szepietowski Jacek C
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego Street 1, Wrocław 50-368, Poland.
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego Street 1, Wrocław 50-368, Poland.
Dermatol Clin. 2018 Jul;36(3):277-292. doi: 10.1016/j.det.2018.02.007. Epub 2018 Apr 26.
End-stage renal disease chronic itch is a frequent symptom that bothers patients with advanced stages of chronic kidney disease. The pathogenesis of the chronic itch symptom is complex and not yet fully understood and includes many metabolic, immunologic, and neurogenic factors. A significant burden of the disease results in decreased quality of life with sleep impairment, depressive symptoms, and increased mortality of affected individuals. No treatment of choice is available; topical therapy (emollients), phototherapy (UV-B), and systemic therapy (antiepileptics, opioid agonists, and antagonists) provide significant relief in varying percentages of patients.
终末期肾病慢性瘙痒是困扰慢性肾病晚期患者的常见症状。慢性瘙痒症状的发病机制复杂，尚未完全明确，包括许多代谢、免疫和神经源性因素。该疾病带来的显著负担导致生活质量下降，出现睡眠障碍、抑郁症状，且受影响个体的死亡率增加。目前尚无特效治疗方法；局部治疗（润肤剂）、光疗（UV-B）和全身治疗（抗癫痫药、阿片类激动剂和拮抗剂）能使不同比例的患者得到显著缓解。
