Mügge A, Reupcke C, Scholz H
Eur J Pharmacol. 1985 Jun 7;112(2):249-52. doi: 10.1016/0014-2999(85)90503-5.
Chronic treatment with propranolol for 6 weeks resulted in a 16.6% increase, over the level in control rats, in myocardial alpha 1-adrenoceptor density as measured by [3H]prazosin binding. The apparent affinity remained unaffected. No changes were observed in beta-adrenoceptor density and apparent affinity as measured by [3H]dihydroalprenolol binding. It is concluded that myocardial alpha 1-adrenoceptors might have a compensatory role under conditions where beta-adrenergic effects are attenuated.
