Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10075, USA.
Department of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, and Göttingen Center for Molecular Biosciences, University of Göttingen, D-37077 Göttingen, Germany.
Science. 2018 Jun 22;360(6395). doi: 10.1126/science.aas9457.
Aouacheria question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.
Aouacheria 对用具有细胞凋亡特征的细胞程序性死亡(A-PCD)来监测当代检测方法的解释提出质疑,尽管我们的研究重点是真菌 A-PCD 对宿主免疫监视和感染结果的影响,但该实验方法结合了多个独立的 A-PCD 标记物和基于真菌而非哺乳动物同源物的遗传操作,以避免任何单一方法相关的局限性。