评论“在肺部实现杀菌免疫依赖于靶向真菌凋亡样程序性细胞死亡”。
Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".
机构信息
ISEM, Institut des Sciences de l'Evolution de Montpellier, Université de Montpellier, CNRS, EPHE, IRD, Montpellier, France.
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Science. 2018 Jun 22;360(6395). doi: 10.1126/science.aar6910.
Abstract
Shlezinger (Reports, 8 September 2017, p. 1037) report that the common fungus , a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.
摘要
施莱辛格（Reports，2017 年 9 月 8 日，第 1037 页）报告称，一种常见的真菌（导致曲霉菌病的原因）会在肺部嗜中性粒细胞的作用下发生依赖半胱天冬酶的细胞凋亡样死亡。然而，他们使用的技术并不能提供可靠的证据证明真菌细胞通过一种蛋白酶信号级联反应死亡，而这种信号级联反应被一种与人类存活素同源的真菌半胱天冬酶抑制剂所阻止。
相似文献
1
Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".评论“在肺部实现杀菌免疫依赖于靶向真菌凋亡样程序性细胞死亡”。
Science. 2018 Jun 22;360(6395). doi: 10.1126/science.aar6910.
2
Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death.肺部的杀菌免疫依赖于靶向真菌凋亡样程序性细胞死亡。
Science. 2017 Sep 8;357(6355):1037-1041. doi: 10.1126/science.aan0365.
3
Mitochondrial Reactive Oxygen Species Enhance Alveolar Macrophage Activity against Aspergillus fumigatus but Are Dispensable for Host Protection.线粒体活性氧增强肺泡巨噬细胞对抗烟曲霉的活性，但对于宿主保护则并非必需。
mSphere. 2021 Jun 30;6(3):e0026021. doi: 10.1128/mSphere.00260-21. Epub 2021 Jun 2.
4
Aspergillus fumigatus Cell Wall Promotes Apical Airway Epithelial Recruitment of Human Neutrophils.烟曲霉细胞壁促进人中性粒细胞向气道上皮顶端的募集。
Infect Immun. 2020 Jan 22;88(2). doi: 10.1128/IAI.00813-19.
5
Response to Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".对“在肺部实现杀菌免疫依赖于靶向真菌凋亡样程序性细胞死亡”一文的评论的回应。
Science. 2018 Jun 22;360(6395). doi: 10.1126/science.aas9457.
6
During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk.在曲霉病感染期间，单核细胞衍生的树突状细胞、中性粒细胞和浆细胞样树突状细胞通过 CXCR3 依赖性串扰增强先天免疫防御。
Cell Host Microbe. 2020 Jul 8;28(1):104-116.e4. doi: 10.1016/j.chom.2020.05.002. Epub 2020 Jun 1.
7
Three-Dimensional Light Sheet Fluorescence Microscopy of Lungs To Dissect Local Host Immune-Aspergillus fumigatus Interactions.肺部三维光片荧光显微镜检查以剖析局部宿主免疫-烟曲霉相互作用。
mBio. 2020 Feb 4;11(1):e02752-19. doi: 10.1128/mBio.02752-19.
8
Induction of innate immunity by Aspergillus fumigatus cell wall polysaccharides is enhanced by the composite presentation of chitin and beta-glucan.烟曲霉细胞壁多糖通过几丁质和β-葡聚糖的复合呈递诱导固有免疫增强。
Immunobiology. 2014 Mar;219(3):179-88. doi: 10.1016/j.imbio.2013.10.003. Epub 2013 Oct 12.
9
[Role of local immunity in invasive pulmonary aspergillosis].[局部免疫在侵袭性肺曲霉病中的作用]
Presse Med. 2001;30(25 Pt 1):1258-64.
10
Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates.白细胞介素 1α 对于抵抗高毒力烟曲霉分离株至关重要。
Infect Immun. 2017 Nov 17;85(12). doi: 10.1128/IAI.00661-17. Print 2017 Dec.
引用本文的文献
1
Current and novel approaches in yeast cell death research.酵母细胞死亡研究中的当前方法与新方法。
Cell Death Differ. 2025 Feb;32(2):207-218. doi: 10.1038/s41418-024-01298-2. Epub 2024 May 7.
2
Programmed Cell Death in Unicellular Versus Multicellular Organisms.单细胞生物与多细胞生物中的细胞程序性死亡。
Annu Rev Genet. 2023 Nov 27;57:435-459. doi: 10.1146/annurev-genet-033123-095833. Epub 2023 Sep 18.
3
Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization.酵母细胞死亡途径需要 AP-3 囊泡运输，导致液泡/溶酶体膜通透性增加。
Cell Rep. 2022 Apr 12;39(2):110647. doi: 10.1016/j.celrep.2022.110647.
4
Dormancy in Cryptococcus neoformans: 60 years of accumulating evidence.新型隐球菌休眠：60 年的积累证据。
J Clin Invest. 2020 Jul 1;130(7):3353-3360. doi: 10.1172/JCI136223.
5
Inhibition of NET-1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway.抑制NET-1通过激活PI3K/AKT信号通路抑制肝癌细胞增殖并促进其凋亡。
Exp Ther Med. 2019 Mar;17(3):2334-2340. doi: 10.3892/etm.2019.7211. Epub 2019 Jan 29.
6
Targeting intrinsic cell death pathways to control fungal pathogens.靶向细胞内在死亡途径以控制真菌病原体。
Biochem Pharmacol. 2019 Apr;162:71-78. doi: 10.1016/j.bcp.2019.01.012. Epub 2019 Jan 17.
7
Whi2 signals low leucine availability to halt yeast growth and cell death.Whi2 信号传递低亮氨酸可用性以停止酵母生长和细胞死亡。
FEMS Yeast Res. 2018 Dec 1;18(8). doi: 10.1093/femsyr/foy095.
8
Do Fungi Undergo Apoptosis-Like Programmed Cell Death?真菌是否经历类似细胞凋亡的程序性细胞死亡？
mBio. 2018 Jul 31;9(4):e00948-18. doi: 10.1128/mBio.00948-18.
9
Response to Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".对“在肺部实现杀菌免疫依赖于靶向真菌凋亡样程序性细胞死亡”一文的评论的回应。
Science. 2018 Jun 22;360(6395). doi: 10.1126/science.aas9457.
本文引用的文献
1
DNA-damage inducible protein 1 is a conserved metacaspase substrate that is cleaved and further destabilized in yeast under specific metabolic conditions.DNA 损伤诱导蛋白 1 是一种保守的 metacaspase 底物，在特定代谢条件下，该蛋白在酵母中被切割并进一步失稳。
FEBS J. 2018 Mar;285(6):1097-1110. doi: 10.1111/febs.14390. Epub 2018 Feb 3.
2
Regulated Forms of Cell Death in Fungi.真菌中细胞死亡的调控形式
Front Microbiol. 2017 Sep 21;8:1837. doi: 10.3389/fmicb.2017.01837. eCollection 2017.
3
Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death.肺部的杀菌免疫依赖于靶向真菌凋亡样程序性细胞死亡。
Science. 2017 Sep 8;357(6355):1037-1041. doi: 10.1126/science.aan0365.
4
Evolution of caspase-mediated cell death and differentiation: twins separated at birth.半胱氨酸天冬氨酸蛋白酶介导的细胞死亡与分化的进化：一母同胞，殊途同归。
Cell Death Differ. 2017 Aug;24(8):1359-1368. doi: 10.1038/cdd.2017.37. Epub 2017 Mar 24.
5
Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis.一种新型细胞死亡诱导结构域的鉴定表明，真菌淀粉样蛋白控制的程序性细胞死亡与坏死性凋亡有关。
Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2720-5. doi: 10.1073/pnas.1522361113. Epub 2016 Feb 22.
6
Caspase substrates and inhibitors.半胱天冬酶底物和抑制剂。
Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a008680. doi: 10.1101/cshperspect.a008680.
7
Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin.通过靶向生存素的腔诱导变构位点来抑制有丝分裂纺锤体和肿瘤生长。
Oncogene. 2012 Apr 12;31(15):1938-48. doi: 10.1038/onc.2011.377. Epub 2011 Sep 5.
8
Caspases in yeast apoptosis-like death: facts and artefacts.酵母凋亡样死亡中的半胱天冬酶：事实与假象
FEMS Yeast Res. 2007 Jan;7(1):12-21. doi: 10.1111/j.1567-1364.2006.00137.x.
9
The Aspergillus fumigatus metacaspases CasA and CasB facilitate growth under conditions of endoplasmic reticulum stress.烟曲霉的 metacaspases CasA 和 CasB 在内质网应激条件下促进生长。
Mol Microbiol. 2007 Jan;63(2):591-604. doi: 10.1111/j.1365-2958.2006.05534.x. Epub 2006 Dec 14.
10
Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.半胱天冬酶特异性抑制剂对木瓜蛋白酶样半胱氨酸蛋白酶和天冬酰胺内肽酶的抑制作用：当反应机制比特异性更重要时
Cell Death Differ. 2003 Aug;10(8):881-8. doi: 10.1038/sj.cdd.4401247.
Zotero 插件