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评论“在肺部实现杀菌免疫依赖于靶向真菌凋亡样程序性细胞死亡”。

Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".

机构信息

ISEM, Institut des Sciences de l'Evolution de Montpellier, Université de Montpellier, CNRS, EPHE, IRD, Montpellier, France.

Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

出版信息

Science. 2018 Jun 22;360(6395). doi: 10.1126/science.aar6910.

DOI:10.1126/science.aar6910
PMID:29930109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7045345/
Abstract

Shlezinger (Reports, 8 September 2017, p. 1037) report that the common fungus , a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.

摘要

施莱辛格（Reports，2017 年 9 月 8 日，第 1037 页）报告称，一种常见的真菌（导致曲霉菌病的原因）会在肺部嗜中性粒细胞的作用下发生依赖半胱天冬酶的细胞凋亡样死亡。然而，他们使用的技术并不能提供可靠的证据证明真菌细胞通过一种蛋白酶信号级联反应死亡，而这种信号级联反应被一种与人类存活素同源的真菌半胱天冬酶抑制剂所阻止。

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FEBS J. 2018 Mar;285(6):1097-1110. doi: 10.1111/febs.14390. Epub 2018 Feb 3.
2
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3
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