Smirnov V Ia, Iasnetsov V S, Kostiuchenkov V N
Farmakol Toksikol. 1985 May-Jun;48(3):77-9.
Thirty-three experiments were made on mongrel dogs operated on according to Basov, with the use of phentolamine, pilocarpine, atropine, histamine and their combinations. It was established that administration of histamine gives rise to an increase in gastric secretion, provided the animals are pretreated with phentolamine or with combined pilocarpine and phentolamine. Histamine-induced gastric secretion considerably decreases, provided the animals are pretreated with atropine and ceases almost completely after administration of combined atropine and phentolamine. It is concluded that the stimulating effect of phentolamine on gastric secretion is caused by an increase in the sensitivity of H2-receptors and cholinoreceptors under blockade of the alpha-adrenoreactive systems.
对按照巴索夫方法进行手术的杂种狗进行了33次实验，使用了酚妥拉明、毛果芸香碱、阿托品、组胺及其组合。结果表明，若动物预先用酚妥拉明或毛果芸香碱与酚妥拉明联合预处理，给予组胺会导致胃液分泌增加。若动物预先用阿托品预处理，组胺诱导的胃液分泌会显著减少，而在给予阿托品和酚妥拉明联合用药后，胃液分泌几乎完全停止。得出的结论是，酚妥拉明对胃液分泌的刺激作用是由α - 肾上腺素能系统受阻断时H2受体和胆碱能受体敏感性增加所致。
