Hrinchenko O A, Ianchuk P I
Fiziol Zh (1994). 2010;56(4):111-20.
In chronic experiments with dogs with gastric fistulas the influence of amino acid taurine on the gastric secretion was investigated. We showed that taurine did not cause acid gastric secretion out of digestion, but increased the gastric secretion stimulated by histamine, increased the contents of gastric acid and pepsine in gastric secretes. When administered either 15 minutes or two hours prior histamine injection, taurine affected the Na+ and K+ concentrations in gastric juice. The greatest changes in the basic indices of gastric secretion were observed 14 hours after administration of taurine. In these experiments the contents of total proteins and components of adenile system in gastric secretes was increased also. Blockade of cholinoreceptors by atropine, benzohexonium and IEM-1678 decreased the effects of taurine on gastric secretion stimulated by histamine. Blockade of a-adrenoreceptors by phentolamine did not prevent the taurine-induced effects on histamine-stimulated gastric secretion. It is established that under conditions of the blockade of beta-adrenoreceptors by obsidane, taurine does not manifest entirely its potentiating influence on the gastric secretion stimulating by histamine. The data obtained indicate that taurine affects gastric secretion stimulated by histamine and realization of this effect occurs through M- and N-cholino- and B-adrenoreceptors.
在对患有胃瘘的狗进行的慢性实验中，研究了氨基酸牛磺酸对胃液分泌的影响。我们发现，牛磺酸在非消化期不会引起胃酸分泌，但会增加组胺刺激引起的胃液分泌，增加胃液中胃酸和胃蛋白酶的含量。在注射组胺前15分钟或两小时给予牛磺酸，会影响胃液中Na+和K+的浓度。在给予牛磺酸14小时后，观察到胃液分泌基本指标的最大变化。在这些实验中，胃液中总蛋白含量和腺嘌呤系统成分也有所增加。阿托品、溴化六甲铵和IEM - 1678对胆碱能受体的阻断降低了牛磺酸对组胺刺激的胃液分泌的影响。酚妥拉明对α - 肾上腺素能受体的阻断并未阻止牛磺酸对组胺刺激的胃液分泌的作用。已证实，在奥昔丹阻断β - 肾上腺素能受体的情况下，牛磺酸并未完全表现出其对组胺刺激的胃液分泌的增强作用。所获得的数据表明，牛磺酸影响组胺刺激的胃液分泌，并且这种作用是通过M - 和N - 胆碱能受体以及β - 肾上腺素能受体实现的。
