Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry Central China Normal University, Hubei, Wuhan 430079, P. R. China.
Chem Commun (Camb). 2018 Jul 5;54(55):7641-7644. doi: 10.1039/c8cc03778g.
A simple and convenient method for N-aminosulfonamide synthesis from the cross-coupling of aryldiazonium tetrafluoroborates and rongalite under metal-free, oxidant-free, and room-temperature conditions is reported. This method does not require an external amine source, with the aryldiazonium tetrafluoroborates participating as both an aryl radical and a potential amine source in the transformation. Mechanistic studies revealed that rongalite could act as a radical initiator, a sulfur dioxide surrogate and a reducing reagent simultaneously in this reaction.
本文报道了一种在无金属、无氧化剂、室温条件下，通过芳基重氮四氟硼酸盐与吊白块的交叉偶联反应来合成 N-氨基磺酰胺的简便方法。该方法无需外加胺源，芳基重氮四氟硼酸盐在转化中既作为芳基自由基，又作为潜在的胺源参与反应。机理研究表明，在该反应中，吊白块可以同时作为自由基引发剂、二氧化硫替代物和还原剂。
