Doly M, Braquet P, Bonhomme B, Vennat J C, Meyniel G
Int J Tissue React. 1985;7(2):111-6.
The isolated retina represents an excellent membrane model since it provides a specific electrophysiological response that is easy to quantify. Therefore the authors have tested the effects of B4, C4 and D4 leukotrienes on this model. In the presence of leukotrienes, electrical response generally decreases and survival duration of the isolated retina is generally shortened. No significant difference between the effects of the three tested products has been found. These results are discussed in relation to, on the one hand, the mechanism of intraretinal generation of its electrophysiological signal and, on the other hand, the leukotrienes' role in inflammatory diseases of the retina.
分离的视网膜是一种出色的膜模型，因为它能产生易于量化的特定电生理反应。因此，作者测试了白三烯B4、C4和D4对该模型的影响。在存在白三烯的情况下，电反应通常会降低，分离视网膜的存活时间通常会缩短。未发现三种受试产品的作用之间存在显著差异。一方面，根据视网膜内电生理信号的产生机制，另一方面，根据白三烯在视网膜炎症性疾病中的作用，对这些结果进行了讨论。
