U.G.C Aparato Digestivo, Hospital Universitario Virgen del Rocío, España.
Aparato Digestivo, Hospital Universitario Virgen del Rocío, España.
Rev Esp Enferm Dig. 2018 Nov;110(11):736-738. doi: 10.17235/reed.2018.5429/2017.
Mesalazine is a drug routinely used in ulcerative colitis and usually has few side effects. There have been reports of uncommon cases of severe mucocutaneous damage, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), induced by salicylates. It is important to diagnose these promptly due to the high morbidity and mortality rates. We describe the case of a 46-year-old female with ulcerative proctitis, who developed SJS following topical mesalazine use. The lesions responded well to intravenous corticosteroids after discontinuation of the drug.
美沙拉嗪是一种常用于溃疡性结肠炎的药物，通常副作用较少。已有报道称，水杨酸盐可引起罕见的严重黏膜皮肤损伤，如史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）。由于发病率和死亡率高，及时诊断这些疾病非常重要。我们描述了一位 46 岁女性溃疡性直肠炎的病例，她在使用局部美沙拉嗪后出现 SJS。停用药物后，静脉注射皮质类固醇治疗有效。
