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5%咪喹莫特乳膏诱发的史蒂文斯-约翰逊综合征:一例报告

Stevens-Johnson induced by imiquimod 5% cream: a case report.

作者信息

Trave Ilaria, Salvi Ilaria, Micalizzi Claudia, Castelli Riccardo, Parodi Aurora, Cozzani Emanuele

机构信息

Department of Dermatology, Dipartimento della Salute (DiSSal), University of Genoa; IRCCS, Ospedale Policlinico San Martino, Genoa, Italy.

出版信息

Dermatol Reports. 2024 Apr 19;16(4):9930. doi: 10.4081/dr.2024.9930. eCollection 2024 Nov 21.

DOI:10.4081/dr.2024.9930
PMID:39749121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11694421/
Abstract

Imiquimod 5% cream is an approved treatment for actinic keratoses, superficial basal cell carcinomas, and anogenital warts. Severe systemic side effects associated with imiquimod 5% cream are rare, although a few cases of erythema multiforme and Stevens-Johnson syndrome have been described. We present a case of Stevens-Johnson syndrome associated with topical treatment with imiquimod of two superficial basal cell carcinomas.

摘要

5%咪喹莫特乳膏是一种经批准用于治疗光化性角化病、浅表性基底细胞癌和肛门生殖器疣的药物。与5%咪喹莫特乳膏相关的严重全身性副作用很少见,尽管已有少数多形红斑和史蒂文斯-约翰逊综合征的病例报道。我们报告一例与外用咪喹莫特治疗两个浅表性基底细胞癌相关的史蒂文斯-约翰逊综合征病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bae/11694421/5a93f214208a/dr-16-4-9930-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bae/11694421/0fc072104e0f/dr-16-4-9930-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bae/11694421/5a93f214208a/dr-16-4-9930-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bae/11694421/0fc072104e0f/dr-16-4-9930-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bae/11694421/5a93f214208a/dr-16-4-9930-g002.jpg

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Am J Case Rep. 2023 Nov 12;24:e941992. doi: 10.12659/AJCR.941992.
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Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症:诊断与治疗的综述。
Medicina (Kaunas). 2021 Aug 28;57(9):895. doi: 10.3390/medicina57090895.
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Aust J Gen Pract. 2020 Oct;49(10):662-664. doi: 10.31128/AJGP-11-19-5145.
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Erythema multiforme induced by topical imiquimod.外用咪喹莫特诱发的多形红斑
Emergencias. 2020 Jun;32(3):219.
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Topical mesalazine as a cause of Stevens-Johnson syndrome.局部美沙拉嗪(柳氮磺胺吡啶)致 Stevens-Johnson 综合征。
Rev Esp Enferm Dig. 2018 Nov;110(11):736-738. doi: 10.17235/reed.2018.5429/2017.
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