Sosnowski Tomasz R, Jabłczyńska Katarzyna, Odziomek Marcin, Schlage Walter K, Kuczaj Arkadiusz K
a Faculty of Chemical and Process Engineering , Warsaw University of Technology , Warsaw , Poland.
b Philip Morris International R&D, Philip Morris Products S.A. (part of Philip Morris International group of companies) , Neuchâtel, Switzerland.
Inhal Toxicol. 2018 Mar-Apr;30(4-5):159-168. doi: 10.1080/08958378.2018.1478916. Epub 2018 Jun 22.
Direct physicochemical interactions between the major components of electronic cigarette liquids (e-liquids): glycerol (VG) and propylene glycol (PG), and lung surfactant (LS) were studied by determining the dynamic surface tension under a simulated breathing cycle using drop shape method. The studies were performed for a wide range of concentrations based on estimated doses of e-liquid aerosols (up to 2500 × the expected nominal concentrations) and for various VG/PG ratios. The results are discussed as relationships among mean surface tension, surface tension amplitude, and surface rheological properties (dilatational elasticity and viscosity) versus concentration and composition of e-liquid. The results showed that high local concentrations (>200 × higher than the estimated average dose after a single puffing session) may induce measurable changes in biophysical activity of LS; however, only ultra-high e-liquid concentrations inactivated the surfactant. Physiochemical characterization of e-liquids provide additional insights for the safety assessment of electronic nicotine delivery systems (ENDS).
通过使用液滴形状法测定模拟呼吸周期下的动态表面张力，研究了电子烟液（电子烟油）的主要成分甘油（VG）和丙二醇（PG）与肺表面活性剂（LS）之间的直接物理化学相互作用。基于电子烟烟雾估计剂量（高达预期标称浓度的2500倍）以及各种VG/PG比例，对广泛的浓度范围进行了研究。结果以平均表面张力、表面张力振幅和表面流变特性（膨胀弹性和粘度）与电子烟油浓度和成分之间的关系进行讨论。结果表明，高局部浓度（比单次抽吸后估计的平均剂量高200倍以上）可能会引起肺表面活性剂生物物理活性的可测量变化；然而，只有超高电子烟油浓度会使表面活性剂失活。电子烟油的物理化学特性为电子尼古丁传送系统（ENDS）的安全性评估提供了更多见解。
