Zhang Liang, Ng Tzi Bun, Lam Jenny Ka Wing, Wang Shi Wei, Lao Lixing, Zhang Kalin Yanbo, Sze Stephen Cho Wing
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, China.
School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR, China.
Curr Protein Pept Sci. 2019;20(3):277-284. doi: 10.2174/1389203719666180622094356.
We discuss the diverse biological activities, therapeutic potential, and clinical applications of peptides and proteins isolated from various yams species including Dioscorea opposita Thunb (Chinese yam), D alata, D japonica (Japanese yam), D pseudojaponica, D batatas (Korea yam), and D cayenensis. Yam peptides and proteins have many pharmacological activities including immunomodulatory, antioxidant, estrogen-stimulating, osteogenic, angiotensin I-converting enzyme inhibiting, carbonic anhydrase and trypsin inhibiting, chitinase, anti-insect, anti-dust mite, lectin, and anti-proliferative activities. Yam peptides and proteins have therapeutic potential for treating cardiovascular diseases, inflammatory diseases, cancers, aging disorders, menopause, and osteoporosis.
我们讨论了从多种山药品种中分离出的肽和蛋白质的多种生物活性、治疗潜力及临床应用，这些品种包括薯蓣（山药）、大薯、日本薯蓣（日本山药）、伪日本薯蓣、参薯（韩国山药）和黄独。山药肽和蛋白质具有多种药理活性，包括免疫调节、抗氧化、雌激素刺激、成骨、血管紧张素I转换酶抑制、碳酸酐酶和胰蛋白酶抑制、几丁质酶、抗昆虫、抗尘螨、凝集素和抗增殖活性。山药肽和蛋白质在治疗心血管疾病、炎症性疾病、癌症、衰老紊乱、更年期和骨质疏松症方面具有治疗潜力。
