1 School of Engineering, Brown University, Providence, RI, USA.
2 Center for Biomedical Engineering, Brown University, Providence, RI, USA.
SLAS Technol. 2018 Dec;23(6):540-549. doi: 10.1177/2472630318775079. Epub 2018 Jun 22.
Technological advances in solid organ tissue engineering that rely on the assembly of small tissue-building parts require a novel transport method suited for soft, deformable, living objects of submillimeter- to centimeter-length scale. We describe a technology that utilizes membrane flow through a gripper to generate optimized pressure differentials across the top and bottom surfaces of microtissue so that the part may be gripped and lifted. The flow and geometry parameters are developed for automation by analyzing the fluid mechanics framework by which a gripper can lift tissue parts off solid and porous surfaces. For the axisymmetric part and gripper geometries, we examine the lift force on the part as a function of various parameters related to the gripper design, its operation, and the tissue parts and environments with which it operates. We believe our bio-gripping model can be used in various applications in high-throughput tissue engineering.
依赖于小型组织构建部件组装的实体器官组织工程技术需要一种新颖的输送方法，适用于亚毫米到厘米长度尺度的柔软、可变形的活体物体。我们描述了一种利用膜流过夹具来在微组织的顶部和底部表面之间产生优化的压力差的技术，以便可以夹持和提起部件。通过分析夹具可以从固体和多孔表面提起组织部件的流体力学框架来开发用于自动化的流动和几何参数。对于轴对称部件和夹具几何形状，我们研究了部件上的提升力作为与夹具设计、操作以及其操作的组织部件和环境相关的各种参数的函数。我们相信我们的生物夹持模型可以在高通量组织工程的各种应用中使用。
