Rodriguez-Salvador Marisela, Fox-Miranda Itzel, Perez-Benitez Baruc Emet, Lopez-Robles Jose Ricardo
Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, Nuevo Leon, Mexico.
Universidad Autónoma de Zacatecas, Zacatecas, Mexico.
Int J Bioprint. 2022 Jun 29;8(3):585. doi: 10.18063/ijb.v8i3.585. eCollection 2022.
Tissue spheroids represent an innovative solution for tissue engineering and regenerative medicine. They constitute an three-dimensional cell culture model capable of mimicking the complex composition of a native tissue on a micro-scale; this model can function as a building block and be assembled into larger tissue constructs. Due to the potential tissue spheroids have for the evolution of the health industry, there is a need to assess the research dynamics of this field. Thus far, there have been no studies on their use as building blocks. To fill this gap, a study was performed to characterize the evolution of research where tissue spheroids were used as building blocks to generate tissue constructs. A scientometric analysis of the literature regarding tissue spheroid technologies was developed by quantification of bibliometric performance indicators. For this purpose, articles published during the period January 1, 2015 - December 31, 2021, from the Scopus database were organized and analyzed. The main subject areas, countries, cities, journals, institutions, and top-cited articles as well as the types of techniques, cells, culture time, and principal applications were identified. This research supports the definition and growth of research and development strategies for new technologies such as tissue spheroids.
组织球状体是组织工程和再生医学的一种创新解决方案。它们构成了一种三维细胞培养模型，能够在微观尺度上模拟天然组织的复杂组成；该模型可作为构建模块，组装成更大的组织构建体。鉴于组织球状体对健康产业发展的潜力，有必要评估该领域的研究动态。迄今为止，尚无关于将其用作构建模块的研究。为填补这一空白，开展了一项研究，以描述将组织球状体用作构建模块来生成组织构建体的研究进展。通过对文献计量绩效指标进行量化，对有关组织球状体技术的文献进行了科学计量分析。为此，整理并分析了Scopus数据库中2015年1月1日至2021年12月31日期间发表的文章。确定了主要主题领域、国家、城市、期刊、机构和高被引文章，以及技术类型、细胞、培养时间和主要应用。这项研究为组织球状体等新技术的研发战略的定义和发展提供了支持。
