尾部衰减：PABP 和 CNOT 产生 mRNA 去腺苷酸化循环。
Tailing Off: PABP and CNOT Generate Cycles of mRNA Deadenylation.
机构信息
Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK.
Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK.
出版信息
Mol Cell. 2018 Jun 21;70(6):987-988. doi: 10.1016/j.molcel.2018.06.009.
PMID:29932908
Abstract
In this issue of Molecular Cell, Webster et al. (2018) and Yi et al. (2018) dissect the mechanisms underlying cytoplasmic mRNA deadenylation by the Ccr4-Not (CNOT) complex. Crucial to this process is the poly(A) binding protein Pab1/PABPC1, which both stimulates and suppresses the activity of different deadenylases.
摘要
在本期《分子细胞》中，Webster 等人（2018 年）和 Yi 等人（2018 年）解析了 Ccr4-Not（CNOT）复合物介导的细胞质 mRNA 去腺苷酸化的机制。这一过程的关键是 poly(A)结合蛋白 Pab1/PABPC1，它既能刺激又能抑制不同脱腺苷酸酶的活性。
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