先有鸡还是先有蛋：微小RNA介导的mRNA翻译调控还是mRNA稳定性调控。
The chicken or the egg: microRNA-mediated regulation of mRNA translation or mRNA stability.
作者信息
Omer Arina D, Janas Maja M, Novina Carl D
机构信息
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Mol Cell. 2009 Sep 24;35(6):739-40. doi: 10.1016/j.molcel.2009.09.003.
PMID:19782024
Abstract
In this issue of Molecular Cell, Fabian et al. (2009) demonstrate that in cell-free extracts from mouse Krebs-2 ascites, microRNA-mediated translational repression precedes target mRNA deadenylation, and identify GW182, PABP, and deadenylase subunits CAF1 and CCR4 as factors required for deadenylation.
摘要
在本期《分子细胞》杂志中，法比安等人（2009年）证明，在从小鼠克雷布斯-2腹水提取的无细胞提取物中，微小RNA介导的翻译抑制先于靶标mRNA的去腺苷酸化，并确定GW182、聚腺苷酸结合蛋白（PABP）以及去腺苷酸化酶亚基CAF1和CCR4是去腺苷酸化所需的因子。
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