Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Cell Microbiol. 2018 Aug;20(8):e12884. doi: 10.1111/cmi.12884. Epub 2018 Jun 29.
Flavivirus replication is intimately involved with remodelled membrane organelles that are compartmentalised for different functions during their life cycle. Recent advances in lipid analyses and gene depletion have identified a number of host components that enable efficient virus replication in infected cells. Here, we describe the current understanding on the role and contribution of host lipids and membrane bending proteins to flavivirus replication, with a particular focus on the components that bend and shape the membrane bilayer to induce the flavivirus-induced organelles characteristic of infection.
黄病毒的复制与膜细胞器的重排密切相关，这些细胞器在其生命周期中为不同的功能分隔。脂质分析和基因缺失的最新进展鉴定了许多宿主成分，这些成分使感染细胞中的病毒复制更加高效。在这里，我们描述了宿主脂质和膜弯曲蛋白在黄病毒复制中的作用和贡献的最新认识，特别关注那些弯曲和塑造膜双层以诱导感染特征性黄病毒诱导细胞器的成分。
